牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响

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1、第26卷第1期阿方学院学杯(医学版)Vo1．26No．12009年2月JournalofHebeiNorthUniversity(MedicalEdition)Feb．2009StudyontheEffectsofLearningandMemoryAbilityforRatsandMiceExposedtoChronicMercuryZHAOWen-tao。ZHANGShun-sans，GAOJie，LIJi-sheng。(1．AnatomyDepartment，CangzhouMedicalCo

2、llege，Cangzhou，061001。Hebei．China；2．CangzhouCenterforDiseaseControlandPrevention，Cangzhou·061000·Hebei，China；3．MilitaryPreventiveMedicineInstitute，ChinesePeople’sArmedPoliceForceMedicalCollege，Tianjin，300162，China)[ABSTRACT]Objective：Tostudythediffere

3、ntdosagesoftaurine-zinccoordinationcompound(Tzc)onresistingtheimpairmentofmercury(Hg)inducedCNSdamage．Methods：Thechosenratsandmiceweredividedintocontrolgroup，Hggroup，Hg+TZCgroup．Theelfc0teddifferencesforlearningmemoryabilitywereob-servedwiththeYmazete

4、standshuttlebeforeandafterexperiment．Results：Mercurycanlendtodecreaseofleaningandmemoryability(P<0．05)。eachzinc-supplementgroupcanmitigatethedamageinducedbymercu’ryindifferentdegree(P<0．05)．Conclusions：TheresistanceeffectofTZConthetoxicofHgisrelatedto

5、thefo-mofzinc-compoundandthedosageofTZC．[KEYWORDS]TZC，Mercury，Learning，Memory牛磺酸锌对慢性染汞大鼠、小鼠学习记忆的影响赵文涛张顺三。高洁李积胜。(1．沧州医学高等专科学校解剖教研室，河北沧州061001；2．河北省沧州市疾病预防控制中心，河北沧州061001；3．武警医学院军事预防医学研究所，天津300162)【摘要】目的：探讨牛磺酸锌(TZC)拮抗汞对神经系统的损害作用。方法：选用健康Wistar大鼠64只，昆明种小鼠

6、60只分别随机分组，对照组、染汞组、汞+TzC组．大鼠采用Y迷宫，小鼠采用穿梭实验，观察染汞组和不同浓度TZC组的鼠学习记忆能力的变化。结果：汞可导致大鼠学习记忆能力下降(P<0．05)，不同浓度的TZC均可缓解汞致大鼠学习记忆能力下降(P<0．05)。结论：TZC在一定程度上能拮抗汞对神经系统毒性作用。【关键词】牛磺酸锌；汞；学习；记忆【中图分类号]R965【文献标识码】A【文章编号]1673—1484(2009)01—0005—03Mercuryisanxenobioticmetalthatb

7、elongstoamercurypotsonlng．kindofhighlydeleteriousenvironmentalpollutants．1MaterialsandMethodsThebiotransformationofmercurychloride(HgC12)1．1Constructionoftheanimalmodelintomethylmercurychloride(CH3HgC1)inaquaticSixty—fourpost—wearingmalewistarrats(sup

8、—environmentsiswell-knownandhumanbeingsarepliedbyTianjinExperimentalAnimalCenter)wereexposedtoconsumptionofcontaminatedfish，shell—randomlydividedintocontrolgroup(drinkingdis—fishandalgae[¨．Byusingthepraxiologymethodthistilledwater)、mercuryexpo