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ID:19152225
大小:18.76 KB
页数:9页
时间:2018-09-29
《白癜风人群雌激素受体基因多态性与临床资料相关性分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、白癜风人群雌激素受体基因多态性与临床资料相关性分析作者:卢宁,高天文,姚庆君,赵明,李凯,杨励,高超【关键词】雌激素受体AssociationbetweenestrogenreceptorgenepolymorphisminvitiligopatientsandthEirclinicaldata【Abstract】AIM:TostudytheassociationbetweenestrogenreceptorαgenepolymorphisminvitiligopatientsandthEIrclinicaldata.METHODS:Polym
2、erasechainreactionrestrictionfragmentlengthpolymorphism(PCRRFLP)wasusedtostudytheERαintron1PvuIIC/T(rs2234693)polymorphismsin6patientswithvitiligo.Genotypesweredeterminedandallelefrequencieswerecomparedtofindtheirrelationshipwiththeirclinicaldata.RESULTS: Thegenotypeandallel
3、efrequencydistributionswerenotsignificantlydifferentamongvitiligopatientswithdifferentsubtypes,sex,onsetage,with/withoutotherautoimmunediseasesandfamilyhistory(P>),whilePvalueswereintherangeofsegmentalandtwogeneralizedtypevitiligopatients(segmentalvsuniversal,P=;segmentalvsc
4、ommon,P=).AndPvalueswerenearwhentheC/Tgenotypefrequencywascomparedbetweenonsetageoflowerthan1yearsoldandof12-20yearsold(P=);Pvalueswerealsolowincomparisonsofgenotype(P=)andallelefrequencies(P=)betweenthemaleandthefemalepatients.CONCLUSION:Whenthegenotypeandallelefrequencieso
5、ftheERαintron1C/Tpolymorphismwerecomparedamongvitiligopatientswithdifferentsubtypes,sex,onsetage,with/withoutotherautoimmunediseasesandfamilyhistory,nosignificantdifferencewasobserved.However,atendencyofsignificantdifferenceswasobservedincomparisonsoffemaleandmalevitiligopat
6、ients,segmentalandgeneralizedtypes,anddifferentonsetage(【Keywords】estrogenreceptoralpha;polymorphism,genetic;vitiligo;clinicaldata【摘要】目的:探讨白癜风人群雌激素受体α基因多态性与其临床资料之间的关系.方法:应用多聚酶链反应―限制性片段长度多态性分析技术,应用两对引物双重检测466例汉族白癜风患者ERα基因内含子1PvuII酶切位点C/T(rs2234693)突变处基因多态性,并比较了该人群雌激素受体基因多态性分布
7、与其临床资料之间的关系.结果:白癜风人群基因内含子1C/T基因型频率及等位基因频率在不同临床类型、性别、发病年龄、病期、伴/不伴自身免疫疾病及有无家族成史之间均无统计学差别(P>),但在皮节型与寻常型之间相比的P值在范围内,,12岁以下与12~20年龄组之间基因型频率相比的P值较接近,男/女基因型频率相比及等位基因频率相比亦较低,有差别趋势.结论:白癜风人群ERα内含子1PvuII酶切位点C/T基因型频率及等位基因频率在不同临床类型、性别、发病年龄、病期、伴/不伴自身疾病及有无家族史之间均无显著差别,但在皮节型与寻常型、发病年龄12岁以下与12
8、~20之间、男女之间有差别明显化的趋势,提示携带C基因可能是儿童期发病、寻常型及女性白癜风患者的易感因素.【关键词】雌激素受体α;多态现象,遗传;白癜
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