联合检测CEA、ADA、LDH及血沉对胸腔积液性质判断的临床意义

《联合检测CEA、ADA、LDH及血沉对胸腔积液性质判断的临床意义》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、安徽医药AnhuiMedicalandPharmaceuticalJournal2013Feb;17(2)•223•联合检测CEA、ADA、LDH及血沉对胸腔积液性质判断的临床意义夏静，闫雪波,刘荣玉(安徽医科大学第一附属医院老年呼吸内科，呼吸病研究所，安徽合肥230032)摘要：目的探讨联合检测血清癌胚抗原（CEA)、血清及胸水乳酸脱氢酶（LDH)、胸水腺苷脱氨酶（ADA)及血沉对胸腔积液性质判断的临床意义。方法以安徽医科大学第一附属医院2011年12月至2012年6月89例住院胸腔积液患者为研究对象，其中25例结核性胸腔积液患者,42例恶性胸腔积液患者,22例炎性胸腔积

2、液患者；采用电化学发光免疫分析法测定血清CEA,酶法（L法）测定血清LDH,速率法测定胸水LDH及ADA,魏氏法测定血沉。结果恶性胸腔积液患者血清CEA含量明显高于结核性及炎性胸腔积液患者；胸水及血清LDH含量在结核性、恶性、炎性胸腔积液患者中比较无显著性差异，但三者胸水LDH含量均明显高于正常范围，结核性胸腔积液患者胸水与血清LDH比值明显高于恶性胸腔积液患者；结核性胸腔积液患者胸水ADA含量明显高于恶性及炎性胸腔积液患者；炎性胸腔积液患者血沉明显高于结核性及恶性胸腔积液患者，结核性胸腔积液患者血沉明显高于恶性胸腔积液患者。结论联合检测胸腔积液患者血清CEA、胸水及血清L

3、DH,胸水ADA及血沉对辅助判断胸腔积液的性质具有重要价值。关键词：胸腔积液;CEA;ADA;LDH;血沉Diagnosticvalueofcombinativedetectionofserumcarcinoembryonicantigen(CEA),adenosinedeaminase(ADA),lactatedehydrogenase(LDH)andESRindifferentialdiagnosisofpleuraleffusionXIAJing,YANXue-bo,LIURong-yu(DepartmentofGeriatricRespiratoryMedicine

4、,theFirstAffiliatedHospitalofAnhuiMedicalUniversity,Hefei,Anhui230032,China)Abstract:ObjectiveToestablishthediagnosticvalueofcombinativedetectionofserumCEA,serumandpleuralfluidLDH,pleuralfluidADAandESRindifferentpleuraleffusionpatients.MethodsFromDecember2011toJune2012,89casesofin-patient

5、swithpleuraleffusionintheFirstAffiliatedHospitalofAnhuiMedicalUniversitywerechosen,including25casesoftuberculouseffusion(TE),42patientswithmalignantpleuraleffusion(MPE)and22casesofinflammatorypatientswithpleuraleffusion(IPE).ThelevelsofserumCEAwereexaminedbyelectrochemilumin-escenceimmuno

6、assaymethod,serumLDHbytheenzymatic(Lmethod),pleuralfluidLDHandADAbyratingmethodandESRbyWestergren.ResultsTheserumCEAofmalignantpleuraleffusionpatientsishigherthanthatofTEandIPEpatients;TheserumandpleuralfluidLDHlevelsinTE,MPE,IPEpatientsshowednosignificantdifference,butthethreepleuraleffus

7、ionLDHlevelsweresignificantlyhigherthanthenormalrange,andtheratioofpleuraleffusionandserumLDHinpatientswithTEwassignificantlyhigherthanthatofpatientswithMPE;ThepleuralfluidADAlevelsofTEweresignificantlyhigherthanthoseoftheMPEandIPE;TheIPEpatientsESRlevelsweres