介入综合治疗亚急性下肢深静脉血栓的临床分析

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1、授予单位代码10089学号或申请号15212中国图书分类号R543.6HebeiMedicalUniversity硕士学位论文学术学位介入综合治疗亚急性下肢深静脉血栓的临床分析研究生：王钊导师：毕伟教授专业：外科学二级学院：第二医院2018年3月目录中文摘要····························································································1英文摘要··························································

2、··································4英文缩写····························································································8研究论文介入综合治疗亚急性下肢深静脉血栓的临床分析前言····························································································9材料与方法···························

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4、·····································································20讨论····························································································22结论····························································································28参考文献·················

5、···········································································28综述血管腔内技术在下肢深静脉血栓的应用研究进展·························31致谢····························································································43个人简历·························································

6、···································44介入综合治疗亚急性下肢深静脉血栓的临床分析摘要目的：下肢深静脉血栓形成(Deepvenousthrombosis，DVT)是临床上常见的血管外科疾病，可以累及不同的年龄段，其部分患者可发展为肺栓塞(Pulmonaryembolism,PE)及下肢静脉血栓后综合症(Post-thrombosissyndrome,PTS)，严重者可致残甚至危及生命，给社会、家庭带来沉重负担及痛苦。在美国，深静脉血栓形成的发病率为每年1/1000人，约1/3未经治疗的存在症状的患者合并PE，PE死亡率仅次于肿瘤

7、及心肌梗死，约为15%。目前认为静脉血流瘀滞、静脉壁损伤及血液高凝状态为致病因素，相互作用致血小板堆积增多，大量白细胞和红细胞聚集，最终形成静脉血栓。其主要症状表现不同，与血栓部位、血栓范围、静脉管腔阻塞程度及侧枝循环建立有关，多为患肢的肿胀及憋痛为主。深静脉血栓的治疗方法包括抗凝、溶栓、经皮机械血栓清除术等，对于急性期下肢深静脉血栓腔内治疗技术及标准抗凝治疗在早期恢复血管通畅及减少远期并发症方面取得了良好的效果，但在我国，由于各种原因部分患者急性期未予就诊而未得到系统治疗，进入亚急性期(发病时间15-30d)后来就诊，血栓为混合性血栓、陈旧性血栓，血栓与血管壁

8、粘连逐渐紧密，部分机化，