基于氯沙坦和辛伐他汀对糖尿病大鼠肾脏nf

《基于氯沙坦和辛伐他汀对糖尿病大鼠肾脏nf》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、基于氯沙坦和辛伐他汀对糖尿病大鼠肾脏NF【目的观察链脲佐菌素（STZ）诱导的糖尿病>P<0.05）。HE染色未见糖尿病肾病特有的结节型或弥漫型肾小球硬化表现，但糖尿病对照组可见明显的肾小管上皮细胞的空泡样变性，而正常或药物治疗组未见相应改变。UAER高达90μg/min以上，明显高于正常对照组（P<0.0001）。（2）辛伐他汀和氯沙坦各自单独治疗均可使以上指标的表达明显抑制（和糖尿病对照比P<0.05），而且辛伐他汀的治疗功能独立于其降脂功能，但均达不到正常对照水平，两药联合使用可使表达水平进一步下降和改善。结论NF-κB、PDGF-B及PKCα的表达对糖尿病

2、肾病起着重要的功能。氯沙坦的肾脏保护功能不同于脂类代谢的功能、氯沙坦和辛伐他汀的联合应用可以更好地保护肾脏，但它们真正的功能机制有待进一步的探究。【氯沙坦辛伐他汀糖尿病肾病蛋白激酶Cα血小板衍化生长因子-B链.【AbstractObjectiveTheexcessiveexpressionsofTGF-β，VEGFinrenaltissueofdiabeticratshasbeenreportedrecentyears，andthechangescouldbeinhibitedechanismisnotveryclear.ToresearchtheeffectsofNF-κB、P

3、KCαandPDGF-BontheprogressionofdiabeticnephropathyandtherenoprotectivemechanismoflosartanandSimvastatinonStreptozotocin-induceddiabetic>n=8，Cgroup)，diabetescontrol(n=13，Dgroup)，diabeticratstreatedg/(kg·d)，bygavage，n=13，D1group］，diabeticratstreatedvastatin［2mg/(kg·d)，bygavage，n=13，D2group］anddi

4、abeticratstreatedvastatin［20mg/(kg·d)and2mg/(kg·d)，bygavage，n=13，D3group］.Allratsofdiabeticgroupseasuredbyimmunohistochemistry，and12-hoururinealbuminuriaexcretionrate(UAER)，plasmacholesterol，plasmatriglycerideandplasmacreatinineinedistry.ResultsAfter8eansofUAERindiabeticcontrolgroupothergroup

5、sandorethan90μg/min.TheimmunohistochemistrystainingofNF-κB，PKCαandPDGF-Binkidneyproximaltublecytoplasmaorethanthatinglomeruler.Epithelialcellsofkidneytubleatoxylin-eosinstaining(HEstaining)bylightmicroscopy.BothlosartanandsimvastatincouldsignificantlyinhibittheexpressionsofNF-κB，PKCαandPDGF-B

6、indiabeticrenaltissue(P<0.05)，butcouldnotmakeitrecovery.binedtreatmentoflosartanandsimvastatincouldinhibittheexpressionsofNF-κB，PKCαandPDGF-Bfurther.Ingeneral，effectsbetvastatinportantactionontheprogressionofdiabeticnephropathy.Itshouldn’tbeignoredthattheymightinjurekidneytuble.Bothlosarta

7、nandsimvastatinhavesignificanteffectondiabeticnephropathy.Therenoprotectiveeffectoflosartanisindependentuponit’seffectofregulatinglipoidmetabolism.binedtreatmentoflosartanandsimvastatincouldfurtherprotectkidneyfromdiabeticinjury.Buttheirexact