1、《乌司他丁对脓毒症患者肾损伤的保护作用》 [Abstract] Objective To explore the protective effects of Ulinastatin for the septic patients with renal injury， to analyze the influence on the prognosis and immune function， and to investigate its possible mechanism， and provide the basis fo
2、r clinical therapy. Methods Forty six patients with sepsis were selected in the People's Hospital of Lishui City from March 2010 to February 2014. They were randomly divided into the control group (22 cases)， who were treated with conventional treatment and nursing
3、， and the observation group (24 cases) were treated with Ulinastatin on the basis of conventional therapy. The blood urea nitrogen (BUN) and serum creatinine (SCr) and Cystatin C (Cystatin C)， T cell subsets were evaluated， the serum tumor necrosis factor-α (TNF-α)
4、 and interleukin -6 (IL-6) level， and acute physiology and chronic health evaluation (APACHE Ⅱ) scores before and after treatment were detected. Results Cystatin， C， BUN and SCr of two groups after treatment were obviously lower than those before treatment， the dif
5、ferences were statistically significant (P < 0.05). Cystatin C， BUN and SCr of the observation group after treatment were (1.21±0.24) mg/L， (14.92±1.23) mmol/L and (210.74±18.36) μmol/L， lower than the control group after treatment [(1.57±0.16) mg/L， (16.12±1.04) m
6、mol/L and (254.33±23.82) μmol/L] (P < 0.05). Compared to before treatment， CD4+， CD8+ and CD4+/CD8+ of two groups， the differences were statistically significant (P < 0.05). CD4+ and CD4+/CD8+ of the observation group after treatment was (43.87±5.04)% and (1.82±0.2
7、9)， higher than that of the control group after treatment [(38.04±4.51)% and (1.30±0.37)] (P < 0.05). CD8+ of the observation group after treatment was (31.92±3.26)%， lower than the control group after treatment [(35.42±3.11)%] (P < 0.05). TNF-α and IL-6 of two gro
8、ups after treatment compared with before treatment， the difference was statistically significant (P < 0.05). TNF-α and IL-6 of the observation gr
