探讨联合检测糖化血红蛋白和胱抑素c对糖尿病早期肾功能损害的诊断价值

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1、探讨联合检测糖化血红蛋白和胱抑素C对糖尿病早期肾功能损害的诊断价值（成都军区八一骨科医院检验科四川成都610031）【摘要】目的:探讨联合检测糖化血红蛋白和胱抑素C对糖尿病早期肾功能损害的诊断价值。方法:随机选择2015年4月-2016年5月间确诊为2型糖尿病的患者90例作为研究组对象，分为单纯糖尿病组45例和早期糖尿病肾病组45例，同期选择45例健康人作为对照组，分别检测糖化血红蛋白和胱抑素C的浓度水平，综合分析结果。结果:早期糖鉍病肾组的糖化血红蛋G和胱抑素C浓度水平均明显高于单纯糖尿病组和健康对照组，差异具有统计学意义（P<0.05）。早期糖尿病肾组患者的糖化血红蛋內

2、浓度水平与胱抑素C浓度水平呈正相关（r值为0.8092，P<0.05）o早期糖鉍病肾组患荞联合检测糖化血红蛋G和胱抑素C的阳性检出率明显高于单独指标的检测结果，差异均具有统计学意义（P<0.05）,并高于单纯糖尿病组患者的联合阳性检出率，差异具有统计学意义（P<0.05）。结论:糖化血红蛋G和胱抑素C均是辅助诊断糖鉍病早期肾功能损害的有效指标,联合检测能够有效提高疾病的检出率，降低漏诊风险。【关键词】糖尿病；糖尿病肾病；糖化血红蛋白；胱抑素C【中图分类号】R44【文献标识码】A【文章编号】1007-8231（2016）26-0147-02Toexplorethediagno

3、sticvalueoftheearlydiabeticrenaldamagebythecombineddetectionofglycosylatedhemoglobinandcystatinCJianJie,DongDagao,ZhongYiming,ZhouLan,ZhaoMin.TheLaboratoryMedicineoftheBayiorthopaedicshospitalofChengDumilitaryarea,Sichuan,China,610031【Abstract】ObjectiveToexplorethediagnosticvalueoftheearly

4、diabeticrenaldamagebythecombineddetectionofglycosylatedhemoglobinandcystatinC.MethodsChoosing90casesofpatientswithdiabeticdiseasefortheexperimentalgroup,45casesofpatientswerethesimplediabetesgroupandtheothersweretheexperimentalgroup,and45caseshealthycheck-upforthecontrolgroup,testingthegly

5、cosylatedhemoglobinandcystatinC,analyzetheresultscomprehensively.ResultsThereweresignificantlyhigheroftheexperimentalgroupoftheglycosylatedhemoglobinandcystatinCresultsthanthesimplediabetesgroupandhealthycontrolgroup(P<0.05).Relatedtoearlydiabeticrenalpatientswithglycatedhemoglobinlevel

6、sandcystatinClevelswerepositively(r=0.8092,P<0.05).ThereweresignificantlyhigheroftheexperimentalgroupofthepositivedetectionratebythecombineddetectionofglycosylatedhemoglobinandcystatinCresultsthantheresultsofindividualindicator(P<0.05),andalsohigherthanthesimplediabetesgroup(P<0.0

7、5).ConclusionTherebothareeffectiveindicatorsoftheglycosylatedhemoglobinandcystatinCforauxiliarydiagnosingtheearlyrenaldamageindiabeticpatients,itcaneffectivelyimprovethedetectionrateofthediseasebythecombineddetection,reducingmisseddiagnosisrisk.【Keywords]Diabe