als发病的朊蛋白样机制—临床表现及肌电图研究

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1、授予单位代码10089学号或申请号20153230中国图书分类号R744.8HebeiMedicalUniversity硕士学位论文专业学位ALS发病的朊蛋白样机制-临床表现及肌电图研究研究生：段士茹导师：刘亚玲教授专业：神经病学二级学院：河北医科大学第二医院2018年3月目录中文摘要············································································································1英文摘要·······································

2、·····································································2英文缩写············································································································4研究论文ALS发病的朊蛋白样机制-临床表现及肌电图研究前言···················································································

3、·························5材料与方法································································································6结果············································································································9附图······················································

4、····················································11附表··········································································································15讨论··········································································································16结论···················

5、······················································································18参考文献··································································································19综述ALS朊蛋白样发病机制的研究进展····················································22致谢·····························

6、·····················································································30个人简历··········································································································31中文摘要ALS发病的朊蛋白样机制-临床表现及肌电图研究摘要目的：从临床表现、肌电图特征研究ALS朊蛋白样发病机制。方法：回顾性分析103例ALS患者一般资料，通过其病史、查体及肌电图特征，观察

7、临床症状及肌电图连续性或非连续性的表现，研究ALS朊蛋白样发病机制，并且对连续型与非连续型的发病年龄、起病部位、性别及病程进行对比。结果：本研究共收入103位患者，临床表现受累节段分型中，连续型47例（48.4%），非连续型48例（51.6%），而肌电图受累节段分型中，连续型90例（87.4%），非连续型13例（12.6%）；48例临床表现非连续型患者中47例缺乏胸髓受累症状的证据。肌电图及临床表现受累连续与非连续型两组间相比，性别、年龄、病程、FRST无