Lab-on-a-displaya new microparticle manipulation platform using a liquid crystal display (LCD)(英文)

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1、Lab-on-a-display:anewmicroparticlemanipulationplatformusingaliquidcrystaldisplay(LCD)WonjaeChoi·Se-HwanKim·JinJangJe-KyunParkReceived:20June2006/Accepted:8September2006/Publishedonline:11October2006⑥Springer-Verlag2006AbstractThispaperreportsanewportablemicrofluidicplatform,"lab-on-a

2、-display,"thatmicroparticlesaremanipulatedbyoptoelectronictweezers(OET)onaliquidcrystaldisplay(LCD).TheOEThasbeenconstructedbyassemblingagroundlayer,aliquidchamber,andaphotoconductivelayer.Withoutlensoropticalalignments,theLCDimagedirectlyformsvirtualelectrodesonthephotoconductivelay

3、erfordielectrophoreticmanipulation.Thelab-on-a-displaywasfirstrealizedbyaconventionalmonochromaticLCDmoduleandalightsourcebrighterthan5,000lux.Itwassuccessfullyappliedtotheprogrammablemanipulationof45μmpolystyrenebeads;morethan100particlesweretransportedwithanopticalimage-drivencontr

4、ol,followingthemovingedgeoftheimageateverymoment.Theeffectsofbeadsizeandbiasvoltageonthemanipulationspeedwerealsoinvestigated.Duetotheportabilityandcompatibilityfordisposableapplications,thisnewplatformhaspotentialforprogrammableparticlemanipulationorchip-basedbioprocessingincludingc

5、ellseparationandbead-basedanalysis.KeywordsMicrofluidics,Lab-on-a-display，Liquidcrystaldisplay(LCD),Optoelectronic,tweezers,Dielectrophoresis,Particlemanipulation1IntroductionThemanipulationofbiologicalcellsandmicroparticlesplaysanimportantroleinmanybiologicalapplications(Verpoorte20

6、03;DittrichandManz2006).Dielectrophoresis(DEP)isafavorablephenomenonforthemanipulationofvariousdielectricparticles(Hughes2002;Krupkeetal.2003;Washizuetal.1994).Generally,DEPutilizestheinteractionforcebetweennonuniformelectricfieldandtheinduceddipolemomentoftheparticle.Duetoitsability

7、tohandlecellsorparticleswithoutanymodificationofthem,ithasbecomeoneofthemostattractivemanipulationtechniquesinamicrofluidicdeviceoralab-on-a-chip.Inrecentstudies,manyresearchgroupshaverevealedthedielectricpropertiesofpolystyrenemicrobeads(Abeetal.2004;ChoiandPark2005),DNA(LaoandHsing

8、2005),bacter