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1、TheRoleofPerioperativeChemotherapyintheTreatmentofUrothelialCancer论文.freelaGoela,e,JohnPhillipsd,e,RonaldD.Ennisa,b,e,MichaelL.Grossbarda,c,e【关键词】Urothelial,canceraDepartmentofMedicine,.freelatology/OncologyandbDepartmentofRadiationOncology,St.Luke’s-RooseveltHospitalCenter,NeentofMedicine
2、,DivisionofHematology/OncologyanddDepartmentofUrology,BethIsraelMedicalCenter,NeCancerCentersofNea;Neoadjuvant;Adjuvant;ChemotherapyABSTRACTCanceroftheurotheliumisthefourthmostmonmalignancyinmenintheU.S.andtheninthmostmoninen.Morethan63,000Americansenand16,200en),andmorethan13,000(8,970men
3、and4,210en)canexpecttodieoftheirdisease.Theapproximate5:1ratioofincidencetomortalityroughlyparallelsthefrequencyofsuperficialtoinvasivedisease.Effortstoimprovethisratiohavegeneratedapotentialparadigmshiftinthetreatmentofurothelialcancer,incorporatingincreasinglyactivechemotherapyintotreatm
4、entregimensforhigh-risktumorsinboththepre-andpostoperativesettings.Thisreviemarizestheevolutionofchemotherapeutictreatmentofurothelialcancerandtherationaleforitsperioperativeadministrationandaddressesthefuturedirectionsofclinicalresearchinthisfield.INTRODUCTIONCanceroftheurotheliumisthefou
5、rthmostmonmalignancyinmenintheU.S.andtheninthmostmoninen1.Morethan63,000Americansenand16,200en),andmorethan13,000(8,970menand4,210en)canexpecttodieoftheirdisease1.Theapproximate5:1ratioofincidencetomortalityroughlyparallelsthefrequencyofsuperficialtoinvasivedisease1.Effortstoimprovethisrat
6、iohavegeneratedapotentialparadigmshiftinthetreatmentofurothelialcancer,incorporatingincreasinglyactivechemotherapyintotreatmentregimensforhigh-risktumorsinboththepre-andpostoperativesettings.Thisreviemarizestheevolutionofchemotherapeutictreatmentofurothelialcancerandtherationaleforitsperio
7、perativeadministrationandaddressesthefuturedirectionsofclinicalresearchinthisfield.RATIONALE:POOROUTESENTALONETumorsthatinvadethedeepmusclelayerofthebladderareassignedstageT2,entofmuscle-invasivecancershashistoricallyprisedsurgicalresectionviaradicalcystectomy
