贝伐单抗脂质体联合离子电渗对兔眼后段给药的分析

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1、-------广州医科大学硕士学位论文freebevacizumabconcentrations，ELISAkitwasused．Thedatawereanalyzedbyt-testandanalysisofvariance．Results：1．Theresultsofocularexamination：Alltheexperimentalanimalswerehealthyduringthewholeproceduals．Therearenoobviouscomplicationsintheeyes，su

2、chaseyeinfections，cornealopacity,cataract，retinalhemorrhageeta1．2.Thecomparisonofdrugconcentration:GroupA、BandC,theaqueoushumorconcentrationofbevaeizumabwas(11.08±0.46)μg/mland(27.53±0.37)μg/mland(38.48±0.15)μg/mlintherighteyes，after24h,respectively.Avitreo

3、usconcentrationofbevaeizumabwas(7.29±0.17)μg/mland(19.25±0.15)μg/mland(31.87±0.25)μg/mlintherighteyes，respectively.Iontophoresisgroup,bevacizumabconcentrationintherighteyesofaqueoushumorandvitreouscavitycomparison.Thedrugconcentrationofaqueoushumorwerehighe

4、rthaninthevitreouscavity,thedifferencewasstatisticallysignificant(P<0.01).Betweeniontophoresisgroup,therewerestatisticallysignificantofdrugconcentrationsinthesameareasthroughvarianceanalysisandcomparisonbetweengroups.Bevacizumabsolutioneyedropsgroup(lefteye

5、ingroupA)，theaqueoushumorandvitreouscavitywerenotdetectedindrugconcentration.Bevacizumabliposomessolutioneyedropsgroup(lefteyeingroupB)，drugconcentrationintheaqueoushumorwas（1.30±0.11）μg/mlandthevitreouscavitywasnotdetectedindrugconcentration.Becausethetwog

6、roupsfailedtodetectdrugconcentrationorconcentrationistoolow,arenotincludedforcomparison.Bevacizumabconcentration(receivedintravitrealinjectedbybevacizumab)inaqueoushumorandvitreouscavitywas(19.37±0.21)μ-----------4万方数据-----------英文摘要g/mland(179.83±0.11)μg/m

7、linthelefteyes.Comparedwiththedrugconcentrationindifferentcurrentintensityofiontophoresis,thedifferencehadstatisticalsignificance,P<0.01.Conclusion：Bevacizumabliposomescombinediontophoresisadministration,nosignificantsideeffects,isasafemodeofadministration.

8、Currentinarangeof0.5～2.5mA，thegreaterthecurrentintensity,bevacizumabliposomesintheeyeoftheimportquantityislarger.Bevacizumabliposomescombinediontophoresiswiththerapeuticsignificance,fordrugconcentratio