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1、乳腺癌c-erbB-2、GST-h>TopoIIa和p53的表达及意义沈艳1黄超有2陈建强3钟日胜1(1广州番禺区何贤纪念医院病理科511400)(2广州番禺区何贤纪念医院普外科511400)(3广州番禺区疗养院511400)【中图分类号】R737.9【文献标识码】A【文章编号】1672-5085(2010)28-0086-03【摘要】目的探讨c-erbB-2、GST-π、TopoIIα和p53蛋白在乳腺癌中表达的意义及相互关系。方法应用免疫组化S-P法检测76例乳腺癌组织中c-erbB-2、GST-π、TopoIIα和p53的表达。结果乳腺癌中c-erb
2、B-2、GST-π、Topo11α和p53的表达率分别为36.8%(28/76)，42.1%(32/76),76.3%(58/76)和47.4(36/76)。c-erbB-2和GST-π的表达与组织学分级和TNM分期有关(P<0.05),p53的表达与组织学分级有关(P<0.05)而与TNM分期无关(P〉0.05),TopoIIα的表达与组织学分级和TNM分期无关(P〉0.05)。TopoIIα的表达与c-erbB-2和p53呈负相关(P<0.05)o结论乳腺癌c-erbB-2、GST-π的表达提示高侵袭性临床病理特征。
3、1^011&3钟3;和乳腺癌的发生、发展可能并无直接关系。【关键词】乳腺癌GST-πTopoIIαc-erbB-2免疫组织化学Expressionofc-erbB-2,GST-π,TopoIIαandp53inBreastCarcinomaanditsSignificanceSHENYanl,HUANGChao-you2,CHENJian-qiang3,ZHONGRi-shengl(IDepartmentofPathology,HEXianMemorialHospitalofPanYuDistrictofGuangzhou,511400，China;2De
4、partmentofGeneralSurgery,HEXianMemorialHospitalofPanYuDistrictofGuangzhou,511400,China；3ConvalescentHospitalofPanYuDistrictofGuangzhou,511400,China)[Abstract]PurposeTostudytheexpression,significanceandrelationshipsofc-erbB-2,GST-π,TopoIIαandp53inbreastcarcinoma.MethodsImmunohistochemistry(
5、methodofSP)wasusedtodetecttheexpressionofc-erbB-2,GST-π,TopoIIαandp53inbreastcarcinoma.ResultsAmong76cases,theexpressionofc-erbB-2,GST-π,TopoIIαandp53was36.8%(28/76)z42.1%(32/76)z76.3%(58/76)and47.4(36/76),respectively;Immunoreactivityofc-erbB-2,GST-πandp53,butnotTopoIIα,
6、wasassociatedwithhistologicgrade(P<0.05);neitherp53norTopoIIαimmunostainingwasassociatedwithTNMstage(P>0.05).theexpressionofTopoIIαcorrelatedinverselywithc-erbB-2andp53content(P<0.05).ConclusionsImmunopositivityofc-erbB-2andGST-πindicatesmoreaggressivelyclinicopathologicchar
7、acteristicsinbreastcarcinoma..TopoIIαmaycontributelittletopathogenesisandprogressionofthebreastcarcinoma【Keywords】breastcarcinomaGST-πTopoIIαc-erbB-2immunohistochemistry肿瘤的发生为多基因参与和多阶段协同作用的结果
