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1、2型糖尿病患者TSH水平与甲状腺结节患病率的相关性研究摘要:目的了解住院2型糖尿病(type2diabetesmellitusT2DM)患者甲状腺结节的患病率,分析T2DM患者临床特征与甲状腺结节的关系,探讨T2DM患者促甲状腺激素(TSH)水平与甲状腺结节的患病率的相关性。方法选择住院T2DM患者450例,收集患者基本资料,要求所有患者行甲状腺超声检查,检测TSH、糖化血红蛋白(HbAlC),并根据患者的TSH水平成5组[1]进行分析统计。结果住院T2DM患者甲状腺结节患病率为70%,女性患病率(81.0%)明显高于男性(59.8%),并随年龄的增加升高(P0.05)。结论住院T2DM患
2、者中,甲状腺结节患病率较高,女性及较大年龄者更为突出,临床上有必要对这些患者进行甲状腺结节筛查。关键词:2型糖尿病(T2DM);促甲状腺激素(TSH);甲状腺结节StudyonCorrelationbetweenSerumLevelofThyroid-stimulatingHormone(TSH)andthePrevalenceofThyroidNodulesinPatientswithType2DiabetesMellitusYANXiao-yunl,LIJuan-juan2,LIHuil,GUOGui-xil,WANGHui-minl,XUJian-xiang1,ZHANGLei2,D
3、ONGYan-hu2(1.DepartmentofClinicalMedicine,WeifangMedicalCollege,Weifang261042,Shandong,China;2.QingdaoEndocrinologyDiabetesHospital,Qingdao266071,Shandong,China)Abstract:ObjectiveTounderstandtheincidenceofthyroidnodulesinhospitalizedpatientswithtype2diabetes(T2DM),andanalyzetherelationshipbetweenc
4、linicalfeaturesofT2DMandthyroidnodules,andexplorethecorrelationbetweenthelevelofTSHandtheprevalenceofthyroidnodulesinpatientswithT2DM.Methods45OpatientswithT2DMwhovisitedQingdaoEndocrineandDiabetesHospitalfromJanuary2013toJunewereenrolledbycollectingthebasicdataanddeterminingTSH,HbA1C,thyroidultra
5、sound.Thepatientsweredividedintofivegroupsaccordingtothepatient’sTSHlevelsforstatisticalanalysis.ResultsTheincidenceofthyroidnodulesinhospitalizedpatientswithT2DMis70%,theprevalencerateofthyroidnoduleswas59.8%inmalepatients,and81.0%infemalepatients,whichwasmorecommoninfemalethaninmale(P0.05).Concl
6、usionTheprevalenceofthyroidnodulesinhospitalizationofdiabeticpatientsishigh,thyroidnodulesshouldbescreened,especiallyinthefemalediabeticpatientsandelderdiabeticpatientswithT2DMKeywords:Type2diabetes;Thyroid-stimulatinghormone(TSH);Thyroidnodules糖尿病与甲状腺疾病均为常见内分泌疾病,近年来,国内外不少研究报道二者的发病率呈上升趋势,有研究表明,两者的
7、发生关联密切[2-3]。国内外研宄发现,糖尿病人群中甲状腺疾病的发生率明显增高,而临床上合并甲状腺结节情况亦十分常见[4]。本研宄对一组住院T2DM患者进行筛查,了解该甲状腺结节的患病率,分析T2DM患者临床特征与甲状腺结节的关系,进一步探讨T2DM患者不同TSH水平甲状腺结节的患病率,研宄其相关性,为糖尿病患者甲状腺疾病高危人群筛查及TSH水平的控制提供临床参考依据。1资料与方法1.1一般资料选取2013年01月〜06