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1、安徽医科大学硕士学位论文includedintothestatisticalanalysis.Results①TCI5~30min,inthemeasuredR2remifentanilgroupandtheR4group,CmwaslowerthanCt,thedifferencewasstatisticallysignificant(P<0.05),TCI40~60min,CmwasclosetoCtvalue,differencewasnotstatisticallysignificant.②EvaluationofRemifentanilTCIsystemp
2、erformancedeviationandaccuracywerewithintheacceptablerangeinclinic.③R2groupofchildrenwithT3timepointMAP,HR,BIS,andAPEItimepointcomparedwithT0weresignificantlyhigher(P<0.05).④R4groupofchildrenwithvariousindicators,whenT3comparedwithT2,thedifferencewasnotstatisticallysignificant(P>0.05).
3、⑤6R2groupofchildrenwithT4timepointMAP,HRdecreasedslightlycomparedwiththeT0pointintime,nostatisticallysignificantdifference(P>0.05).⑥R4groupofchildrenwithT4timepointcomparedwithT0;MAP,HR,BIS,andAPEIpointdecreasedsignificantly(P<0.05).ConclusionRemifentanilfor2ng/mland4ng/ml,theideaofhig
4、h-TCI-I-typesystemspharmacokineticparametersofthedeviation,precisionintheclinicallyacceptablerange.Inaddition,theconcentrationoftarget-controlledinfusionofremifentanil4ng/ml,whilecompositetarget-controlledinfusionofpropofol,canmaintainthevalueofBISandAEPIinclinicalanesthesiastate,atthe
5、sametimecankeepintraoperativehemodynamicrelativelystable.[Keywords]Children;blooddrugconcentration;target-controlledinfusion;remifentanil;chromatography;liquid9安徽医科大学硕士学位论文英文缩写一览表英文缩写英文全名中文全名AEPIauditoryevokedpotentialsindex听觉诱发电位指数AAIA-LineARXindex听觉诱发电位指数TCItarget-contralledinfusion靶
6、控输注BAEPbrain-stemauditoryevokedpotentials脑干听觉诱发电位MLAEPmiddlelatencyauditoryevokedpotentials中潜伏期听觉诱发电位LLAEPlonglatencyauditoryevokedpotentials长潜伏期听觉诱发电位BISbispectralindex脑电双频指数CSIcerebralstateindex脑状态指数Cmmeasuredconcentration实测血药浓度Cttargetconcentration靶浓度PEperformanceerror执行误差MDPEmedian
7、performanceerror偏离度MDAPEmedianabsoluteperformanceerror精确度BPbloodpressure血压MAPmeanarterialpressure平均动脉压HRheartrate心率ECGelectrocardiogram心电图EEGelectroencephalogram脑电图SpO2pulseoxygensaturation脉搏氧饱和度ETCO2end-tidalexpirationcarbondioxide呼气末二氧化碳HPLChighperformanceliquidchromatography高效液相色谱
