中药茵陈承气汤对重症急性胰腺炎大鼠凝血功能的影响

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1、tissueinratsbyretrogradeinjectionof4％sodiumdeoxycholatemethodofsevereacutepancreatitisinratsinducedbysevereacutepancreatitis(SAP)，ChinesemedicinetreatmentgroupandmodelgroupSAPproducedthesameratmodel，theformermodelinl2hand12hafterthemodeloralgavageYinchenchengqiTangliquid2ml／g，theratsonthepr

2、othrombintime(PT)，activatedpartialthromboplastintime(APTT)，fibrinogen(FIB)andinternationalnormalizedratio(INR)comparedtoeachother．Results：(1)PT：mildextensionofPTofthemodelgroup，comparedwiththecontrolgroupdidnothavestatisticallysignificantdifferences(P>0．05)，traditionalChinesemedicinetreatme

3、ntgroupcomparedwiththemodelgrouphasbeentoshortenthePT，thedifferenceisnotstatisticallysignificant(P>O．05)，Chinesemedicinetreatmentgroupcomparedwiththecontrolgrouptherewasnosignificantdifference(P>0．05)．(2)APTT：modelgroupwithmildAPTTprolonged，comparedwiththecontrolgroupdidnothavestatistically

4、significantdifferences(P>O．05)，traditionalChinesemedicinetreatmentgroupcomparedwiththemodelgroup，APTThasbeenshortened，thedifferenceisnotstatisticallysignificant(P>O．05)，therewasnosignificantdifferenceChinesemedicinetreatmentgroupcomparedwiththecontrolgroup(P>0．05)．(3)FIB：FIBofthemodelgroupw

5、assignificantlyhigher，comparedwiththecontrolgroupwithastatisticallysignificantdifference(P<0．01)，traditionalChinesemedicinetreatmentgroupcomparedwiththemodelgroupFIBdecreasedsignificantly(P

6、ontrolgroupdidnothavestatisticallysignificantdifferences(P>0．05)，traditionalChinesemedicinetreatmentgroupcomparedwiththemodelgrouphadnosignificantchangesinINR，thedifferenceisnotstatisticallysignificant(P>0．05)，Chinesemedicinetreatmentgroupcomparedwiththecontrolgrouptherewasnosignificantdiff

7、erence(P>0．05)．Conclusion：YinchenchengqiTangcaneffectivelyreducesevereacutepancreatitisinratbloodfibrinogen(FIB)content，toimprovebloodcoagulationinratswithsevereacutepancreatitisseverityofdysfunctionfor4elinicaltreatmentofSAPtoprovidethetheoreticalbasisa