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1、HypotHesisandtHeoryarticlepublished:15February2011doi:10.3389/fneur.2011.00006ChineseischemicstrokesubclassificationS.Gao1,Y.J.Wang2*,A.D.Xu3,Y.S.Li4andD.Z.Wang51DepartmentofNeurology,PekingUnionMedicalCollegeHospital,ChineseAcademyofMedicalSciences,P
2、ekingUnionMedicalCollege,Beijing,China2DepartmentofNeurology,BeijingTiantanHospital,CapitalMedicalUniversity,Beijing,China3DepartmentofNeurology,TheFirstAffiliatedHospitalofJinanUniversity,Guangzhou,China4DepartmentofNeurology,RenjiHospital,ShanghaiJi
3、aotongUniversitySchoolofMedicine,Shanghai,China5IllinoisNeurologicalInstituteStrokeNetwork,OSFHealthcareSystems,DepartmentofNeurology,UniversityofIllinoisCollegeofMedicineatPeoria,Peoria,IL,USAEditedby:Accurateclassificationofstrokehassignificantimpac
4、tonpatientcareandconductionofstrokeDavidS.Liebeskind,Universityofclinicaltrials.ThecurrentsystemssuchasTOAST,SSS-TOAST,KoreanTOAST,andA–S–C–OCaliforniaLosAngeles,USAhavelimitations.Withtheadventofnewimagingtechnology,thereisaneedtohaveamoreReviewedby:
5、accuratestrokesubclassificationsystem.Chineseischemicstrokesubclassification(CISS)JoseG.Merino,SuburbanHospital,USAsystemisanewtwostepsystemaimsattheetiologyandthenunderlyingmechanismofaNersesSanossian,Universityofstroke.Thefirststepclassifystrokeinto
6、fivecategories:largearteryatherosclerosis(LAA),SouthernCalifornia,USAincludingatherosclerosisofaorticarchandintra-/extracraniallargearteries,cardiogenicstroke,WenguiYu,UniversityofTexasSouthwesternMedicalCenteratpenetratingarterydisease,otheretiology,
7、andundeterminedetiology.ThesecondstepistoDallas,USAfurtherclassifytheunderlyingmechanismofischemicstrokefromtheintracranialandextracranial*Correspondence:LAAintotheparentartery(plaqueorthrombosis)occludingpenetratingartery,artery-to-arteryY.J.Wang,Dep
8、artmentofNeurology,embolism,hypoperfusion/impairedemboliclearance,andmultiplemechanisms.AlthoughBeijingTiantanHospital,CapitalclinicalvalidationofCISSisbeingplanned,CISSisaninnovativesystemthatoffersmuchmoreMedicalUniversity,Beijing100053,Chin
