火针联合消痤饮治疗痰瘀结聚型痤疮的临床疗效观察

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1、中图分类号：R89；R36；R39硕士学位论文火针联合消痤饮治疗痰瘀结聚型痤疮的临床疗效观察院（系）、所中西医结合学院研究生姓名杨茜学科、专业皮肤病与性病学导师姓名杨文信教授二Ο一二年四月目录火针联合消痤饮治疗痰瘀结聚型痤疮的临床疗效观察„„111.1中文摘要„„„„„„„„„„„„„„„„„„„„„31.2英文摘要„„„„„„„„„„„„„„„„„„„„„51.3前言„„„„„„„„„„„„„„„„„„„„„„„91.4临床研究„„„„„„„„„„„„„„„„„„„„„111.5结果„„„„„„„„

2、„„„„„„„„„„„„„„„201.6讨论„„„„„„„„„„„„„„„„„„„„„„„271.7结论„„„„„„„„„„„„„„„„„„„„„„„431.8参考文献„„„„„„„„„„„„„„„„„„„„„441.9英汉缩略词对照表„„„„„„„„„„„„„„„„„502致谢„„„„„„„„„„„„„„„„„„„„„„„513痤疮的中西医治疗进展（综述）„„„„„„„„„„„522火针联合消痤饮治疗痰瘀结聚型痤疮的临床疗效观察摘要目的：观察火针联合消痤饮治疗痰瘀结聚型痤疮的临床疗效及复发率。方法：

3、将90例痰瘀结聚型痤疮患者随机分为三组：治疗组、火针对照组、西药对照组，每组患者各30例。治疗组采用火针治疗联合口服消痤饮加减，火针对照组单纯采用火针治疗，西药对照组采用口服罗红霉素联合外用维A酸乳膏、克林霉素磷酸酯凝胶。每组均连续治疗4周。根据《中药新药临床研究指导原则（试行）痤疮疗效判定标准》分别对三组患者治疗前后皮损情况进行评分，并对治疗后进行安全性评价。治疗4周后，观察总体疗效。治疗后2个月对治疗有效患者进行随访，观察复发率。结果：三组患者治疗前后症状评分比较：治疗组，治疗前积分28.00±2

4、.61，治疗后积分4.64±4.25，治疗前后症状评分比较，t=24.766，P<0．001，具有极显著差异；火针对照组，治疗前积分28.90±1.90，治疗后积分7.79±1.97，治疗前后症状评分比较，t=21.367，P<0．001，具有极显著差异；西药对照组，治疗前积分27.48±2.91，治疗后积分10.81±5.88，治疗前后症状评分比较，t=13.202，P<0．001，具有极显著差异。治疗4周后，三组总体疗效比较：治疗组28人中，痊愈19人，显效7人，有效1人，无效1人，痊愈率67.8

5、6%，总有效率96.43％；火针对照组29人中，痊愈9人，显效11人，有效3人，无效6人，痊愈率31.03%，总有3效率79.31％；西药对照组27人中，痊愈9人，显效12人，有效1人，无效5人，痊愈率33.33%，总有效率81．48％。三组治疗后的2总体疗效经卡方检验，X＝6.10，P＝0.045，三组疗效差异有统计学意义。治疗后2个月，对三组治疗痊愈、显效及有效的患者进行随访，并观察其复发率情况。治疗组4例复发，复发率15.38%；火针对照组9例复发，复发率37.50%；西药对照组10例复发，复发

6、率40.91%。2三组治疗后复发间隔比较，经统计学处理，X＝6.038，P＝0.049，具有统计学意义。不良反应：西药对照组出现5例，主要表现为局部皮肤干燥、脱屑及胃肠道不适；火针对照组与治疗组各出现2例，主要为局部疼痛。不良反应均较轻微，胃肠不适者给予胃黏膜保护药，皮肤干燥、脱屑嘱其皮肤保湿，火针治疗后局部疼痛者冷敷后疼痛即消失。结论：治疗4周后，与火针对照组、西药对照组相比，治疗组总有效率均高于对照组，P＝0.045，差异有统计学意义；对三组患者治疗前后皮损类型、皮损数量、皮损肿痛、皮损颜色、出油

7、情况进行症状评分，P<0.001，说明各组治疗前后具有极显著性差异；治疗后2个月对三组治疗有效例数进行随访，治疗组复发率明显低于火针对照组和西药对照组，P＝0.049，差异具有统计学意义。因而证实，火针联合消痤饮治疗痰瘀结聚型痤疮是行之有效的，同时其复发率低，副作用小，值得临床应用推广。关键词：火针；消痤饮；痰湿结聚；痤疮；临床观察4Observationoftheclinicaleffectsofacnebelongingtothetypeofaccumulationofphlegmandblood

8、stasistreatedbyfire-needlecombinedwithXiaocuodecoctionAbstract:bjective:Toobservetheclinicaleffectandreoccurrencerateofcombiningfire-needlingandXiaocuodecoctionintreatmentofaccumulationofphlegmandbloodstasis.Methods:Divide90cases