资源描述：
《盐酸左西替利嗪联合白芍总苷治疗儿童慢性特发性荨麻疹的临床研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、盐酸左西替利嗪联合白芍总昔治疗儿童慢性特发性尊麻疹的临床研究周小强李高峰罗玉香薛重重韶关学院医学院附属医院广东粤北人民医院皮肤科摘要：口的观察盐酸左西替利嗪联合口芍总昔治疗儿童慢性特发性尊麻疹的疗效及安全性。方法选取100例慢性特发性尊麻疹患儿为研究对象，随机分成治疗组和对照组(各50例)。两组均采用口服盐酸左西替利嗪口服液，其中治疗组在口服盐酸左西替利嗪口服液的同时加用白芍总昔胶囊，疗程为12周，分别在治疗前及治疗后第2、4、8、12周吋对患者的症状体征积分做评估以评价疗效，同吋记录不良反应事件，治疗前、治疗12周后检查血常规、肝肾功能及心电图。停药后6周及12周后观察复发情
2、况。结果治疗组在治疗第14天及第28天时，其有效率分别为76.0%及88.0%,明显高于对照组(52.0%和66.0%)。两组患者主要临床症状评分均明显低于治疗前，而治疗后第14天及第28天治疗组风团持续发作时间及发作频率均低于单用对照组，且在停药后第6周及第12周，复发率分别为12.0%及16.0%,低于对照组(32.0%和38.0%)(P<0.05)。对照组和治疗组的不良反应发生率分别为10.0%及&0%,两组差异无统计学意义(P>0.05)。结论盐酸左西替利嗪联合白芍总百治疗儿童慢性特发性尊麻疹安全、有效，疗效及复发率均优于单用左西替利嗪，值得在临床上推广运用。关键词：盐
3、酸左西替利嗪;口芍总昔;慢性尊麻疹;特发性;儿童;作者简介：薛重重，Ema订:zxq217217@126.com收稿日期：2017-08-05ClinicalResearchofChronicIdiopathicUrticariaTreatedwithLevocetirizineandTotalGlucosidesofPeonyinChildrenZHOUXiao-qiangLIGao-fengLUOYu-xiangXUEChong-chongAffiliatedHospitalofMedicalSchool,ShaoguanUniversity;DepartmentofDer
4、matology,GuangdongAobeiPeople'sHospital;Abstract：ObjectiveToobservethetherapeuticeffectsandsafetyoflevocetirizineandtotalglucosidesofpeony(TGP)onchronicidiopathicurticariainchiIdren.MethodsAtotalof100chi1drenofchronicidiopathicurticarialwereselectedasthesubjeetsandwererandomizedintoatreatmen
5、tgroupandacontrolgroup,50casesineachone.Inbothofthegroups,levocetirizineoralliquidwasused.Additionally,inthetreatmentgrup,TGPcapsuleswereadded.Thedurationoftreatmentwas12weeks.Separate!y,beforetreatment,inweeks2,4,8and12aftertreatment,thescoresofsymptomsandphysicalsignswereassessedaswellasth
6、etherapeuticeffects.Theadversereactionswererecorded.Beforetreatmentandin12weeksoftreatment,thebloodroutine,liverandkidneyfunctionsandEEGweretested.Therecurrencewasobservedaftermedicationdiscontinuityfor6and12weeks.ResultsOntheday14andday28oftreatment,inthetreatmentgroup,theeffectivcrateswere
7、76-0%and88.0%,remarkablyhigherthanthecontrolgroup(52.0%and66.0%)•Thescoreofclinicalsymptomswaslowerremarkablyascomparedwiththatbeforetreatmentinthetwogroups.Onday14and28aftertreatment,thepersistentdurationandattackfrequencyofwindwheelsinthetreatmen
