血管紧张素ⅱ致压力反射重调定对大鼠血压、心率与心率变异性的影响

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1、●英文论著摘要EffectsofAngiotensinⅡCausingBaroreflexResettingonBloodpressure、HeartRateandHRVinRatsIntroductionHeartratevariability(HRV)isthetimevarianceofsinusbeat—to—beatinaperiodoftime．HRVreflectsthetenseandbalanceofautonomicnervoussystem(ANS)．BesidestheeffectsofANS，endocrinefactors，bodyt

2、emperature，bodypositionandmentalfactorsalsoaffectingheartratevariability．Therenin-an舀otensinisoneoftheendocrinefactorsinfluencingHRV．AngiotensinII(AngII)isthemostconsiderablebioactivecompoundofRAS，whichreducesthebaroreflexbradycardiaresponseviaangiotensinIIreceptors1(AT)．Baroreceptor

3、responsesareveryrapid，actingwithinafewsecondstocompensateforanysuddenchangeinbloodpressure，e．g．increasinginarterialpressureleadtoreducingtheheartrateviamodulatingtheactivityinsympathetic,sympatheticvasoconstrictorandparasympatheticnerves．Theresettingpointofthebaroreflexisareferencele

4、velofthemeanarterialpressure．IthasbeensuggestedthattheeffectofresettingofthecardiacbaroreflexcausedbycirculatingAngIIismediatedviatheATlreceptors．Patientswithessentialhypertensionandcongestiveheartfailure，concentrationoftheirplasmaAngIIarehigherthanhealthypeople，whiletheindexoftheirH

5、RVarelowerthanthehealthypeople．ThestudyofourlaboratorysuggestedthatintravenousinfusionofAngIIcandecreasetheindexofHRV，butthepropermechanismofitseffectsarestillunkown．WepresumethattheeffectscausedbyintravenousinfusionofAnglItoHRVaremediatedbyitsresettingactiononthebaroreflexcontrolofH

6、R．Therefore，thepresentstudyusedanesthetizedrats，microinjectedtheATlinhibitorinordertoeliminatetheeffectofAngIIonbaroreflexandanalyzedwhetherthechangesofHRVcausedbyintravenousinfusionofAngIIreferthebaroreflexresettingeffect．TheexperimentalsoobservsthechangesofHRVafterATinjection．5Mate

7、rialsandMethods1．AnimalsandexperimentAdultmaleWistar280g'--320舀obtainedfromtheExperimentalAnimalCenter，ChinaMedicalUniversity．Animalswerecagedindividuallyandhadfreeaccesstofoodandwater．Beforeexperimenteachratwasplacedindividuallyinaplasticcageadaptingtheexperiment，lightanddarknesswer

8、ealternatedw