支架法胃空肠吻合的动物实验分析

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1、浙江大学硕士学位论文l即amtomy.ThePyloruswasligatedandbloekadedwithasilk.InthecontrolgrouP，handsewnanastomosesusingaeontinuoussingle一layersuturewith4一0absorbablesuturewerePerformed.InthestudygrouP，theanastomoseswereeonstruetedwithSteflt.Onthe1othPostoPerativedayX一rayobservationwasPerformedwithdilutedmethylglu

2、caminediatrizoateinjectedorallyviaeatheter.Onday3or14PostoPeratively沉malswereanaesthetizedagainandarelaParotomywerePerformedthroughthePreviousineision.AfterexPloringabdominaleavityearefully，determinedanastomoticburstingPressureusinginvivomethod，thendetachedtheadhesionsaroundtheanastomosis，andthean

3、astomotiesegmentwasexeisedfor0.semwidetissuesamPle.HalfoftheanastomotiesamPlewasstoredat一80oCforhydroxyProlineassay，andhalfwasimmediatelyfixedin10%formaldehydesolutionforhistoPathologieexamination.Results:1.Anastomosistime:AnastomosistimeinstentgrouP(11.9士l.gmin)wassignifieantlyshorterthaninhandse

4、wngrouP(21.7士2.3min;P<0.01).2.Imageology:Injeetingdilutedmethylglucaminediatrizoate，showedthatgastriebodydeveloPed，theeontrastagentPassedthroughtheanastomosissmoothlyandafferentlooPandefferentlooPdeveloPedwell:nodi肋sionofcontrastageniwasseenintheabdominaleavity.UnderthedynamiePersPeetive，noeoniras

5、tagentthroughthePylorieWasseen·3.Generalobservation:OnthethirddayafteroPeration，theanastomotiealignmentwasgoodinbothhandsewnandstentgrouPs;onthe14thdaymaeroseoPieaPPearaneeoftheanastomoticsitewasalwaysgoodinbothhandsewnandstentgrouPseventhoughaeireularfibrotieringwasalwaysPresent.4.Anastomotieburs

6、tingPressure:OnthethirddayafteroPeration，theanastomotieburstingPressureinStentgrouP(18.2士1.6kPa)wassignifieantlyhigherthanthatinhandsewngrouP(11，7土3.okPa:P<0，05):onthe14thday，theanastomotieburstingPressurehadnodiffereneebetweenthetwogrouPs.5.HydroxyProlineeoneentration:Onthethirddayor14thdayaftero

7、Peration，thehydroxyProlineeoncentrationhadnodiffereneebetweenstentgrouPandhandsewngrouP·6，HistoPatholog》·:Onthethirdda)不afteroPeration.theanastomotieinflammationwasobviousandgranuloeyteswerethePredominanteelltyPe