资源描述：
《中西医结合治疗中轻度活动期狼疮性肾炎的临床疗效观察及研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、提要目的：综合观察中西医结合治疗轻中度活动期狼疮性肾炎(LN)的临床疗效，探讨中西医结合治疗的思路与优势。方法：将60例轻中度活动期的狼疮性肾炎患者按1:l比例随机分为治疗组和对照组。治疗组在联合免疫抑制剂治疗的基础上，配合中药方剂治疗，对照组单使用激素联合免疫抑制剂治疗，观察各组病例中患者纳入时及治疗3个月期间，临床症状、体征、血常规、血沉、尿常规、补体C3、C4、24小时尿蛋白定量、肝肾功能及自身抗体等指标，研究分析两组方案的临床疗效、化验指标、激素用量及不良反应发生的情况等。结果：(1)治疗组方案在
2、疾病疗效及证候疗效方面均具有显著效果，其总有效率高于对照组，差异有统计学意义（P<0.05）；(2)治疗组治疗后24h尿蛋白定量、uRBC改善显著优于于对照组(24小时尿蛋白定量：P<0.01，uRBC：P<0.05)；治疗组治疗后血沉下降显著优于对照组（P<0.01）；（3）治疗组激素使用量明显低于对照组，差别有统计学意义(P<0.01)；(4)治疗组不良反应发生率低于对照组，差别有统计学意义(P<0.05)。结论：在提高轻中度活动期狼疮性肾炎患者的临床疗效、改善实验室指标、降低不良反应的发生率、减少激
3、素使用量等方面，中西医结合治疗组疗效优于对照组。关键词中西医结合；狼疮性肾炎；轻中度活动期；系统性红斑狼疮CombinetraditionalChineseandwesternmedicinetreatmentofmildactiveperiodoftheclinicalcurativeeffectoflupusnephritisobservationandresearchSpeciality:InternalMedicineofTCMRheumaticDiseaseAuthor:YANGMEITutor
4、:Prof.FuXinliAbstractObjective:ToobservetheclinicaleffectsofcombiningtraditionalChineseandwesternmedicinetreatmentonmildlyormoderatelystageoflupusnephritis(LN)，todiscussthethinkingandadvantageofcombiningtraditionalChineseandwesternmedicinetreatment.Method
5、:60casesofpatientsoflupusnephritisinmildlyormoderatelystagearedividedintothetreatmentgroupandcontrolgroupwith1:lscalerandomly.Intreatmentgroup,onthebasisofthehormonetherapywithChinesemedicaltreatment,controlgroupusehormonetherapyalone,observetheclinicalsy
6、mptoms,signs,androutineblood,ESR,C3,C4,routineurine,quantitativeindexesof24-hoururinaryprotein,kidneyandliverfunctionandantibodiesofgroupcasesintreatmentofpatients,andduringthesixmonths,analysistheclinicaleffectsofthescheme,hormoneusageandadversereactionc
7、ondition,etcofthetwogroups.Results:(1)Inthetreatmentgroupofprogramefficacyindiseasehavesignificanteffect,thetotaleffectiveratehigherthanthat,thedifferencewasstatisticallysignificant(P<0.05);Treatmentgroup,theefficacyofprogramsinthesyndromehavesignificante
8、ffect,thetotaleffectiveratehigherthanthat,thedifferencewasstatisticallysignificant(P<0.05);(2)Aftertreatment,the24hurineprotein,uRBCdeclinewassignificantlylowerthanthecontrolgroup(24-hoururineproteinquantity:P<0.01,
