丹红注射液对气虚血瘀型急性心肌梗死溶栓后再灌注损伤的临床研究

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1、福建中医药大学硕士学位论文丹红注射液对气虚血瘀型急性心肌梗死溶栓后再灌注损伤的临床研究姓名：张国山申请学位级别：硕士专业：中西医结合临床指导教师：刘文捷201206丹红注射液对气虚血瘀型急性心肌梗死溶栓后再灌注损伤的临床研究中文摘要目的：观察丹红注射液对气虚血瘀型急性心肌梗死溶栓后再灌注损伤的临床研究。方法：将60例急性心肌梗死经溶栓后患者随机分为治疗组与对照组，各30例。治疗组在常规西药治疗基础上于溶栓之日起即开始静滴丹红注射液，对照组予单纯西药干预：两组疗程均为7天。观察两组问指标有：评价溶栓后心律失常发生率及不良事件发生率，测定NT—Pro—BNP、cTnI、CK-MB及Hs-CRP的

2、水平变化情况，评价患者的胸痛缓解情况。结果：①溶栓后3h内治疗组心律失常的发生率为50％，明显低于对照组76．7％(P40．05)②治疗组和对照组在溶栓后，治疗组梗死后心绞痛及心力衰竭的发生率低于对照组，但两组之间无显著性差异(20％vs26．7％，P)O．05；3．3％vs6．7％，P>O．05)；两组住院期间均没有发生死亡及再次心肌梗死。③治疗组和对照组在溶栓后，治疗组CK-MB、cTnI峰值浓度、发病至峰值时间和恢复正常时问均低于对照组(p

3、具有统计学意义(p40．05)⑤治疗组总有效率为96．7％，明显高于对照组73．3％(P

4、tionAbstractobjective：ToobservetheclinicaleffectofReperfusionTraumaafterThrombolysisinAcuteMyocardialInfarctionofQideficiencyandbloodstasissyndrometreatedwithDanhong删ection．Methods：All60patientsofReperfusionTraumaafterThrombolysisinAcuteMyocardialInfarctionwererandomlydividedintotwogroups，including

5、thetreatmentgroup(n=30)andthecontrolgroup(n=30)．Eachgroupcontains30cases．Thecontrolgroupacceptedwesternmedicineonly,whilethetreatmentgroupacceptedDanhongInjectioninadditionalexceptthesalTlemedicineinthecontrolgroup．Eachcourseofthetreatmentlasted7days．Observedtheindexasfollowed：theincidenceofarrhyth

6、mia&adversereaction，thechangesofNT-Pro—BNP,cTnI，CK-MB&Hs—CRPandtheremissionofthoracicpain．Results：1吼，theincidenceofarrhythmiainthetreatmentgroupwassignificantlylowerthanthecontrolgroupafterthrombolysiswithin3h(P<0．05)．2删，afterthrombolysis，itWaSfoundthattheincidenceofanginaandheartfailurewerelowerin

7、thetreatmentgroupthanthecontrolgroup，butitshowednodifferencebetweenthesetwogroups(P>O．05)．Duringhospitalization，bothgroupswereneitherdeathnorre—myocardialinfarction．3m，afterthrombolysis，itshowedthatCK-MB，cT