内质网应激在高糖诱导系膜细胞表型转化中作用研究

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1、目录缩略语表..............................................................................................................................1英文摘要..............................................................................................................................3中文摘要..............................

2、................................................................................................6论文正文内质网应激在高糖诱导系膜细胞表型转化中的作用研究............................91.前言.....................................................................................................................92.材料与方法...............

3、.................................................................................................113.结果....................................................................................................................224.讨论.........................................................................

4、...........................................32全文结论.........................................................................................................................39参考文献.........................................................................................................................4

5、0文献综述内质网应激在糖尿病肾病中的研究进展......................................................47参考文献.........................................................................................................................51在读期间发表论文.....................................................................................

6、........................54致谢.............................................................................................................................55第三军医大学硕士学位论文缩略语表缩写英文名称中文名称HGMCsHumanglomerularmesangialcells人肾系膜细胞4-PBA4-phenylbutyricacid4-苯基丁酸DNDiabeticnephropathy糖尿病肾病HGHighglucose高糖ESRDEn

7、d-stagerenaldisease终末期肾病EREndoplasmicreticulum内质网ERSEndoplasmicreticulumstress内质网应激UPRunfoldedproteinresponse未折叠蛋白反应Grp78Glucoseregulatedprotein78葡萄糖调节蛋白78XBP1X-boxbindingprotein1X-盒剪切蛋白1PERKPKR-likeERkinase蛋白激酶样