解毒汤治疗热毒内蕴型iga肾病的临床研究

《解毒汤治疗热毒内蕴型iga肾病的临床研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、提要目的：观察解毒汤治疗热毒内蕴型IgA肾病的临床疗效，探讨中西医结合治疗本病的优势，为进一步改良及推广配方打下基础。方法：本研究收集热毒内蕴型IgA肾病患者60例，随机分为2组，治疗组、对照组各30例。对照组给予抗感染、降压、降脂、抗凝等西医基础治疗，治疗组在西医基础治疗上加用解毒汤，2个月后观察患者临床症状、体征及实验室检查指标的变化，并对症状及体征进行量化评分，判定其疗效。结果：从中医量化评分来看，治疗组显效率为60%，有效率为20%，总有效率为80%；对照组显效率为36.7%、有效率为20%，总有效率为56.7%，治疗组总有效率高于对照组，统计学有显著性差异（P＜0.05）。

2、治疗组用药后积分与用药前积分相比具有显著的统计学意义（P＜0.01）。治疗前后两组尿红细胞计数、24h尿蛋白定量比较，P值均小于0.05，具有统计学意义。比较两组患者治疗后临床疗效，治疗组愈显率为50.0%，总有效率为86.67%；对照组愈显率为26.67%，总有效率为66.67%，两组比较有统计学意义（P＜0.05）。两组治疗后对肾功能无明显影响。结论：解毒汤治疗热毒内蕴型IgA肾病，能显著减少患者尿红细胞计数及24h尿蛋白定量，改善患者血尿、咽喉肿痛、口干咽燥等症状，显示出解毒汤治疗本病的优势，是否有助于提高原发性IgA肾病的远期疗效有待大样本的进一步研究。关键词解毒汤；原发性I

3、gA肾病；热毒内蕴型ClinicalStudyonidiopathicIgAnephropathyofheattoxinaccumulatinginsidewithJie-duDecoctionSpeciality:KidneyDisease,NephropathyMedicineofTCMAuher:LuoCaihuiTutor:Prof.MiJieAbstractObjective:ToinvestigatetheeffectofJie-duDecoctiontreatingidiopathicIgAnephropathyofheattoxinaccumulatinginside

4、onthebasisofwesternmedicinetreatment.ToexploretheadvantagesandfeasibilityofcombiningtraditionalChineseandwesternmedicinetreatingidiopathicIgAnephropathyandlaythefoundationforfurtherimproverpromotionformula.Methods:60patientswithidiopathicIgAnephropathyofheattoxinaccumulatinginsideweredividedint

5、o2groupsatrandom,eachgroupis30cases.Thecontrolgroupweretreatedwithbasicmedicine,suchasanti-infectionstep-downlipid-loweringandanticoagulant.whiletheexperimentaltreatmentgroupweretreatedwithbasicmedicineandJie-duDecoction.Thecourseoftreatmentis2months.Wewouldobservethesubjectsoflaboraryexaminati

6、onbeforeandafterexperiment,recordedthechangeofpatients'clinicalsymptoms,thengradedthesymptomsandsignswithquantitatively,atlastobservedthecurativeeffects.Results:CompareThegradeofTCMsymptoms,theobviouslyeffectiveratioofJie-duDecoctiontreatinggroupis60%,theeffectiveratio20%,thetotaleffectiveratio

7、is80%；theobviouslyeffectiveratioofcontrolgroupis36.7%,theeffectiveratio20%,thetotaleffectiveratiois56.7%；Theobviouslyeffectiveratioofthetreatinggroupwassignificantlyhigherthanthecontrolgroup,IntheJie-duDecoctiontreatinggroup，itiss