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1、AntibodyTherapeuticsinCancerMarkX.SliwkowskiandIraMellmanScience341,1192(2013);DOI:10.1126/science.1241145Thiscopyisforyourpersonal,non-commercialuseonly.Ifyouwishtodistributethisarticletoothers,youcanorderhigh-qualitycopiesforyourcolleagues,clients,orcustomersbyclickin
2、ghere.Permissiontorepublishorrepurposearticlesorportionsofarticlescanbeobtainedbyfollowingtheguidelineshere.Thefollowingresourcesrelatedtothisarticleareavailableonlineatwww.sciencemag.org(thisinformationiscurrentasofSeptember13,2013):Updatedinformationandservices,includ
3、inghigh-resolutionfigures,canbefoundintheonlineversionofthisarticleat:onSeptember13,2013http://www.sciencemag.org/content/341/6151/1192.full.htmlAlistofselectedadditionalarticlesontheScienceWebsitesrelatedtothisarticlecanbefoundat:http://www.sciencemag.org/content/341/6
4、151/1192.full.html#relatedThisarticlecites60articles,19ofwhichcanbeaccessedfree:http://www.sciencemag.org/content/341/6151/1192.full.html#ref-list-1www.sciencemag.orgDownloadedfromScience(printISSN0036-8075;onlineISSN1095-9203)ispublishedweekly,exceptthelastweekinDecemb
5、er,bytheAmericanAssociationfortheAdvancementofScience,1200NewYorkAvenueNW,Washington,DC20005.Copyright2013bytheAmericanAssociationfortheAdvancementofScience;allrightsreserved.ThetitleScienceisaregisteredtrademarkofAAAS.AntibodiessuccesseshaveledtoaplethoraofADCsinclin-R
6、EVIEWicaldevelopment(seebelow).Last,therecentapprovalofipilimumabhasAntibodyTherapeuticsinCancerintroducedyetanothertherapeuticstrategyforanticancerantibodies,namelyactiveimmunother-apy(9).IpilimumabblockstheactivityoftheMarkX.SliwkowskiandIraMellmannegativeregulatorofT
7、lymphocytes,CTLA4,resultingintheactivationofapatient’simmuneInarelativelyshortperiodoftime,monoclonalantibodieshaveenteredthemainstreamofcancerresponsetocancer.Thisexcitingapproachhastherapy.Theirfirstusewasasantagonistsofoncogenicreceptortyrosinekinases,buttodayalready
8、demonstratedlong-term,durablebenefit.monoclonalantibodieshaveemergedaslong-soughtvehiclesforthetargeteddeliver
