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1、成都中医药大学硕士学位论文WithdrawalRating:Comparedwiththecontrolgroup,modelgroupwithdrawalscorewassignificantlyhigherthanthecontrolgroup,statisticallysignificant,P<0.05;comparedwiththemodelgroup,withdrawalscoreofCIgroupandEAgroupwassignificantlylower,withstatisticalsignifi
2、cance,P<0.05;comparedwithCIgroup,EAgroupwithdrawalscorehasnostatisticalsignificance,P>0.05.Comparedwiththeblankgroup,TheexpressingofNR1inhippocampusandspinalcordfrommorphinewithdrawalmicehasnodifference(P>0.05);TheexpressingofNR2B、CCKinhippocampusandNR2A、NR2B、C
3、CKinspinalcordaresignificantincreased(P<0.05).Comparedwiththemodelgroup,theexpressingofCCKinhippocampusfromCIgroupisobviouslyreduced(P<0.05);NR2B、CCKinhippocampusandNR2A、NR2BinspinalcordfromEAgroupareobviouslyreduced(P<0.05);ThedifferenceofNR1、NR2Binhippocampus
4、andNR1、NR2A、NR2B、CCKinspinalcordfromCIgrouparenotsignificant(P>0.05);ThedifferenceofNR1andNR1、CCKfromEAgrouparenotsignificant(P>0.05);ComparedwiththeCIgroup,thedifferenceofNMDAreceptorandCCKinspinalcordandhippocampusarenotsignificant(P>0.05).Thesecondpartofexpe
5、rimentComparedwiththeblankgroup,theexpressingofNR1inhippocampusandspinalcordissignificantreduced,theexpressingofNR2B、CCKinhippocampusandNR2A、NR2B、CCKinspinalcordaresignificantincreased(P<0.05).Comparedwiththemodelgroup,theexpressingofCCKinhippocampusandspinalco
6、rdfromCIgroupareobviouslyreduced(P<0.05);NR1inhippocampusissignificantincreasedandCCKinspinalcordfromEAgroupareobviouslyreduced(P<0.05);ThedifferenceofNR1、NR2BinhippocampusandNR1、NR2A、NR2BinspinalcordfromCIgrouparenotsignificant(P>0.05);ThedifferenceofNR2B、CCKa
7、ndNR1、NR2A、NR2BfromEAgrouparenotsignificant(P>0.05);ComparedwiththeCIgroup,thedifferenceofNR1inhippocampusfromEAgroupissignificantincreased(P<0.05),thedifferenceofotherNMDAreceptorandCCKinspinalcordandhippocampusarenotsignificant(P>0.05).Conclusions4万方数据成都中医药大学
8、硕士学位论文(1)ThelevelofNMDAreceptorandCCKinhippocampusandspinalcordfrommorphinewithdrawalandtolerancemiceissignificantlydifferentcomparedwiththeblankgroup(P<0.05),promptingNMDAr
