老年男性心力衰竭患者性激素水平调查及与同龄健康男性的比较

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1、维普资讯http://www.cqvip.com20至笠鲞第6期ChinJCardiol，June2005。Vo1．33No．6·心脏功能与心力衰竭．老年男性心力衰竭患者性激素水平调查及与同龄健康男性的比较陈倩李小鹰李江源张万义李洪涛刘芳【摘要】目的了解老年男性心力衰竭(心衰)患者性激素水平及与心功能之间的关系。方法临床诊断为慢性心衰的男性住院患者共100例，年龄在60～87(70．35±8．63)岁，超声心动图检查左室射血分数≤0．45，同时观察健康老年男性4O0例[(71．254-6．81)岁]作为正常对照。采集其晨起静脉血，低温离心后

2、取血清，测定总睾酮、游离睾酮(FT)、脱氢表雄酮硫酸酯(DHEAS)、性激素结合球蛋白(SHBG)、雌二醇、黄体生成素(LH)、卵泡刺激素(FSH)水平，并在同龄心衰患者及健康男性之间进行比较。结果(1)心衰患者DHEAS水平随着年龄的增加降低(P<0．05)，而SHBG、LH、FSH水平则随着年龄的增加而增加(P<0．05，P<0．01)。(2)与同龄健康男性相比，心衰患者总睾酮、丌、雌二醇、DHEAS明显降低(P<0．01)，LH、FSH差异无统计学意义。SHBG水平显著增加(P<0．01)。(3)丌水平与左室射血分数呈显著正相关(r：

3、0．279，P=0．034)。结论老年男性心衰患者的雄激素水平显著降低，且丌水平与心衰程度呈负相关。【关键词】心力衰竭，充血性；附睾分泌蛋白质类；老年人Acomparativesurveyofsexhormoneslevelsbetweenelderlymen、thchronicheartfailureandnormalelderlysubjectsCHENQian‘，LIXiao—ying，LIJiang-yuan，ZHANGWQln一，HHong—tao，HUFang．DepartmentofGeriatricCardiology，PG

4、eneralHospital，Beijing100853，ChinaCorrespondingauthor：LIXiao—ng，Email：lixy@m．3f．cei．gov．Cn【Abstract】ObjectiveTounderstandthesexhormonelevelsinelderlymenwithchronicheartfailureandtherelationshipbetweensexhormonelevelsandheartfunction．MethodsOnehundredmalepatientsdiagnosedch

5、ronicheartfailureclinicallyagedfrom60to87wereselectedinthisstudy．A11patientsleftventricularejectionfractionwerelessthan0．45．Fourhundredelderlyhealthymenwerestudiedascontro1．BloodsampleswerecollectedinthemorningandTF，丌，DHEAS，SHBG，E2，LH，FSHweremeasured．Theresultswerecompared

6、withthehormonelevelsofhealthymenwiththesamemeanage．Results(1)Inelderlymenwithchronicheartfailure，thelevelofDHEASWasdecreasedwit}lage(P<0．05)．However，thelevelsofSHBG，LH，FSHwereincreasedwithage(P<0．05，P<0．01)．(2)ComparedwithhealthymenthelevelsofT／"，fTr，E2andDHEASweredecrease

7、dsignificantly(P<0．O1)andthelevelofSHBGWassignificantlyincreased(P<0．01)．(3)ThelevelofFTWaspositivelycorrelatedwit}lLVEF(r=0．279．P=0．034)．ConclusionTheandrogenlevelsinelderlymalepatientswithchronicheartfailureweredecreasedsignificandyandthelevelofFTWasnegativelycorrelatedw

8、it}ldegreeofheartfailure．【Keywords】Heartfailure，congestive；Epididymalsecretoryproteins；Ag