seh基因敲除治疗stz诱导的小鼠糖尿病肾病的作用及其机制

《seh基因敲除治疗stz诱导的小鼠糖尿病肾病的作用及其机制》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、分类号学号D201078354学校代码10487密级博士学位论文sEH基因敲除治疗STZ诱导的小鼠糖尿病肾病的作用及其机制学位申请人：陈光志学科专业：内科学指导教师：汪培华教授汪道文教授答辩日期：2013年5月AdissertationsubmittedtoHuazhongUniversityofScienceandTechnologyfortheDegreeofDoctorofMedicineEffectsandMechanismsofsEHGeneDisruptiononStreptozotocin-inducedDiabeticNeph

2、ropathyinMicePh.D.Candidate:GuangzhiChenMajor:InternalMedicineSupervisor:Prof.PeihuaWangProf.DaowenWangHuazhongUniversityofScience&TechnologyWuhan430074,P.R.ChinaMay,2013独创性声明本人郑重声明，本学位论文是本人在导师指导下进行的研究工作及取得的研究成果的总结。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的研究成果。对本文的研究做出贡献的

3、个人和集体，均已在文中以明确方式标明。本人完全意识到本人将承担本声明引起的一切法律后果。学位论文作者签名：日期：年月日学位论文版权使用授权书本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索，可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。保密□，在_____年解密后适用本授权书。本论文属于不保密□。（请在以上方框内打“√”）学位论文作者签名：指导教师签名：日期：年月日日

4、期：年月日目录英文缩略词表···················································································1中文摘要···························································································3英文摘要·············································································

5、············12研究背景·························································································22第一部分sEH基因敲除改善STZ诱导的小鼠糖尿病肾病的作用及其机制····25第二部分sEH基因沉默抑制TNF-α诱导的人肾小管上皮细胞凋亡的作用及其机制························································································

6、······47第三部分外源性EETs抑制TNF-α诱导的人肾小管上皮细胞凋亡的作用及其机制·································································································54全文讨论·························································································65全文总结······························

7、···························································70参考文献·························································································72文献综述·························································································80参考文献···················

8、······································································86附录1攻读学位期间撰