天钩降压胶囊的研究论文

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1、PreparationandEvaLuationofTiangouJiangyaCapsuLeSpeciaLty:TraditionaLChineseMedicineAuthor:WangXinTutor:DaiLongAbstractObjective:TopreparateandevaLuatetheTraditionaLChineseMedicinenamedTiangouJiangyaCapsuLeusedtotreathypertensivedisease,andthen,studyonitspreparationp

2、rocess,quaLitystandard,preliminarystabiLityandpharmacodynamicsinvestigationresearch.Methods:Pharma?codynamicsexperimentresuLtsisanimportantindexeforthechoiceofthepreparationprocess.Anointedrateandthecontentofgastrodin，baica-Lin，paeonoLandmitrinermineareusedtodetermi

3、nethedetaiLtechnoLogicaLparameterbysingLefactorexperimentandorthogonaLexperiment.ThemoLdingtechnoLogicaLisduetothemobiLityandmoistureabsorptionofthepowder.AppropriateidentificationoffiveHerbsweremadeby丁LC;gastrodinandbaicaLineweremeasuredrespectivelybyHPLC.SampLeswe

4、reretainedinroomtemperatureforpreLiminarystabiLitytestandpharmacodynamics.ResuLts:PaeonoLiscoLLectedbydistiLLationandthenpreparatedforpaeonoL-P-cy-cLodextrin.Gastrodiarhizome,EucommiaecortexandtheresideofMoutanortexwereextractedbywaterandrefinedbythemethodofLime-H2S

5、0.rEthanoLPrecipitation.UncariaramuLuscumunciswasextractedbywater70%aLcohoLandrefinedbythemethodofaLkaLine-sodiumchLoridePrecipitation.ScutellariaeradixwereextractedbywaterandrefinedbythemethodofacidityPrecipitation.Thepowderwasaddedto15gSi02formakingcapsuLes.Spotsw

6、ereobtainedfromthetestsolutionsandwithoutinterference.ThepurityofgastrodinwasnoLessthan2.1%andthepurityofbaicaLinwasnoLessthan5.0%.12monthsstabiLitytestshowseachindexcompLywiththerequirements.ThestudiesofthepharmacodynamicsindicatedthatitcanreducethebLooclpressureof

7、theratsandthedogs.TheacuteandtheLong-termtoxicitytestshowedthatthecapsuLeissafe.ConcLusion:ThepreparationprocessoftheTiangouJiangyaCapsuLewassteady；thequaLityoftheCapsuLecanbecontroLLedandthedeterminationmethodscanbereproduced；ThesafeandeffectiveCapsuLecanbeusedtotr

8、eathypertensivedisease.KeywordsTiangouJiangyaCapsuLe;hypertensivedisease;Lime-H2S04~EthanoLPrecipitation；gastrodin;baicaLin.目录弓丨W1第1章文献综述3