基于全外显子捕获测序技术的心境障碍家系易感基因筛选及验证

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1、分类号：R749.4学校代码：10114密级：学号：DR2015008基于全外显子捕获测序技术的心境障碍家系易感基因筛选及验证WholeexomesequencingidentifiednovelsusceptibilitygenesresponsibleformooddisorderinaChinesepedigreeandvalidatedinvitroandvivo研究生：杨春霞指导教师：张克让教授专业名称：精神病与精神卫生学研究方向：心境障碍的基础与临床学位类型：学术学位所在学院：第一临床医学院

2、中国山西二〇一八年五月二十日目录中文摘要.............................................................................................................................Ⅰ英文摘要........................................................................................................

3、.....................Ⅵ常用缩写词中英文对照表.................................................................................................Ⅺ前言.........................................................................................................................

4、..........11材料与方法..................................................................................................................131.1临床资料收集及评定...........................................................................................131.2主要实验试剂和仪器....

5、.......................................................................................151.3家系样本初步筛选易感基因实验........…………………………………………181.4易感基因人群频率验证........................................................................................191.5易感基因人群表达验证………………

6、………………………………………….201.6细胞实验验证…………………………………………………………………….231.7GEO芯片数据验证………………………………………………………………282结果...........................................................................................................................292.1初步筛选心境障碍家系易感基因..............

7、..........................................................292.2MAPKAP1位点rs78809014遗传学验证............................................................332.3人群表达水平验证易感基因MAPKAP1............................................................352.4细胞水平验证MAPKAP1作用机制…

8、…………………………………………432.5MAPKAP1信号通路与心境障碍……………………………………………….463讨论...........................................................................................................................563.1心境障碍的遗传学研究.......................