hedgehog信号通路在大鼠急性胰腺炎腺泡细胞凋亡中的作用

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1、授予单位代码10089学号或申请号20123016HebeiMedicalUniversity硕士学位论文专业学位Hedgehog信号通路在大鼠急性胰腺炎腺泡细胞凋亡中的作用研究生：杨鑫铖导师：冯志杰教授专业：内科学（消化系病）二级学院：河北医科大学第二医院研究起止日期：2014年4月至2015年2月交稿日期：2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交

2、流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。r-...//VO•.月、日；河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章:纖^年、月P曰目录中文摘要·····························

3、················································1英文摘要·············································································4英文缩写·············································································8研究论文Hedgehog信号通路在大鼠急性胰腺炎腺泡细胞凋亡中的作用前言·············

4、································································10材料与方法····································································11结果·············································································22附图······································

5、·······································24附表·············································································32讨论·············································································34结论·························································

6、····················38参考文献·······································································39综述急性胰腺炎细胞凋亡机制的研究进展··································41致谢···················································································51个人简历··················

7、···························································52中文摘要Hedgehog信号通路在大鼠急性胰腺炎腺泡细胞凋亡中的作用摘要急性胰腺炎(acutepancreatitis,AP)是一种由多种病因导致的急性炎症反应，起病急骤，临床表现多样，轻度患者治疗后短期内即可恢复，预后良好，而重度AP病情进展迅速，可诱发全身炎症反应综合征(systemicinflammatoryresponsesyndrome,SIRS)和多器官功能障碍综合征(multipleo

8、rgandysfunctionsyndrome,MODS)，病死率高达30%~50%。目前关于AP的发病机制还未完全阐明，近年来随着研究的深入，人们发现细胞凋亡在AP的发生发展中具有不可忽视的作用。AP中胰腺腺泡细胞损伤主要表现为凋亡和坏死。细胞坏死时各种消化酶和炎症介质随着细胞膜的破坏而释放，从而导致剧烈的炎症反应；而凋亡是程序