活血化瘀通络中药对糖尿病胃轻瘫大鼠rhoarock信号转导通路的影响

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1、授予单位代码10089学号或申请号20122205蚵於(£钭走豸HebeiMedicalUniversity硕士学位论文科学学位活血化瘀通络中药对糖尿病胃轻瘫大鼠RhoA/ROCK信号转导通路的影响研究生：侯冬杰导师：孙玉凤教授专业：中西医结合临床二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研究所获得的研究成果，其知识产权归河北医科大学所有。河北医科大学有权对本孥位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报

2、的专利等知识产权均归河北医科大学所有。否则，承担相应法律责任。.：？:丨研究生签名：使考杰导师签杳；二级学院领f盖章：.姆¥斤月玫日河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：作A杰导师签章:)/乂年}月>？日目录中文摘要·············································································1英文摘要···

3、··········································································4英文缩写·············································································9研究论文活血化瘀通络中药对糖尿病胃轻瘫大鼠RhoA/ROCK信号转导通路的影响前言·············································································10材料与方法·········

4、···························································11结果……………………………………………………………………22附图·············································································25附表·············································································29讨论····································

5、·········································31结论·············································································36参考文献·······································································37综述RhoA-ROCK信号转导通路在糖尿病并发症中作用·······························································

6、····················40致谢···················································································49个人简历·············································································50中文摘要活血化瘀通络中药对糖尿病胃轻瘫大鼠RhoA/ROCK信号转导通路的影响摘要目的：糖尿病胃轻瘫(DGP)是一种继发于糖尿病(DM)基础上，以恶心、发作性呕吐、厌食、早饱感及餐后腹胀为主要临床表

7、现；在排除[1]胃机械性梗阻的条件下出现胃扩张、胃蠕动减慢和胃排空延迟，是糖尿病患者常见的一种并发症，严重危害患者的身体健康。据报道糖尿病[2-4]患者DGP发病率高达30%-50%。近年来国内外对糖尿病胃轻瘫发病机制的报道众多，主要是与神经病变、高血糖、胃肠激素紊乱、Cajal间质细胞（ICC）病变、微血管病变、胃肠平滑肌病变等因素有关。近年来研究发现胃肠平滑肌病变在糖尿病胃轻瘫的发生发展中起到非常重要的作用。胃肠道平滑肌是胃肠道动力的核心单位，各种因素最终都要通过胃肠道平滑肌来发挥调控胃肠道动力的作