Advanced Organic Lab Experiments.pdf

《Advanced Organic Lab Experiments.pdf》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、AdvancedOrganicLabExperimentsAdvancedOrganicLabExperiments●Technique1.IdentificationOfUnknownCompounds●Technique2.FlashChromatography.●Technique3.AdvancedChemicalInformationTechnology●Technique4.PreparativeVacuumSublimation●Technique5.AdvancedMolecularModelling●Technique6.ReactionsInLiqu

2、idAmmonia●Technique7.VacuumLineTechniqueAndAnaerobicHandling●Technique8.ReactionInAPressureBottle●Technique9.AdvancedNMRSpectroscopyAnd3DInterpretation●Technique11.ReactionsOfOctal-2-Ones●Technique12.CatalyticHydrogenationAtAtmosphericPressure●Technique15.ReactionsInLiquidAmmonia●Techniq

3、ue16.ReductionsWithLithiumAluminiumHydride●Technique18.OzonolysisOfAnOlefin●Technique19.PhotochemistryOfSantonin●Technique20.Multi-StageSynthesesCopyright(c)ICSTMChemistryDepartment,1994.http://www.ch.ic.ac.uk/GIC/organic_lab.html[06-12-80:10:35]http://www.ch.ic.ac.uk/local/organic/1.htm

4、lA1:ADVANCEDIDENTIFICATIONSAttempttoidentifythecompoundAandthenaturalproductN.Warning:Caremustbeexercisedwhenhandlingandworkingwiththe'unknown'compounds.Asasensibleprecaution,assumethemtobehazardous(manyare)andavoidanyskincontact,inhalationofvapouroringestion.CompoundAi.Purifythematerial

5、bydistillationand/orrecrystallisation.Recordthem.p.or,ifliquid,theb.p.andtherefractiveindex.ii.Recordthei.r.,n.m.r.andu.v.spectra.iii.Submitasampleofyourpurifiedcompoundformicroanalysis.Thesubmissionformsareavailableattheservicecounter.Completedforms,towhichasmallpolytopsamplevialcontain

6、ingafewmgs.ofyourunknownAisattached,shouldbehandedinviaNickDavies.Theformwillbereturnedtoyou(after1-2weeks)withthecorrectpercentagecompositionfiguresandthemolecularweightinserted.Youwillbeassessedupontheaccuracyofyourresults.iv.Analysethephysical,spectralandmicroanalyticaldatainordertoar

7、riveatastructurefortheunknown.v.Ifatthisstage,theidentityofthecompoundisstilluncertain,itwillbenecessarytomakeasuitablederivative(~100mg).Yourdatawillhaveproducedalternativestructuressochooseaderivativewhichyouknowwilldistinguishbetweenthese.Asasafetyprecaution,discussthe