mir29在铝致脑内aβ沉积过程中的作用

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1、分类号:R13学校代码：10114密级:学号：BS2010036MiR29在铝致脑内Aβ沉积过程中的作用TheMechenismofMiR29InvolvedintheDepositionofAmyloid-βInducedbyAluminum研究生：王林平指导教师：牛侨教授专业名称：劳动卫生与环境卫生学研究方向：化学物的神经毒性学位类型：学术学位所在学院：公共卫生学院中国山西二〇一五年三月十八日目录中文摘要...............................................................I英文摘要..........

2、..................................................................................................................VII常用缩写词中英文对照表..............................................................................................XIII前言........................................................

3、...........................................................................1第一部分铝对大鼠脑内miR29、BACE和Aβ的影响.................................................61材料与方法.....................................................................................................................61.1实验材料.

4、.................................................................................................................61.2实验方法..................................................................................................................81.3统计分析方法.......................................

5、.................................................................172结果...........................................................................................................................172.1实验动物基本情况..............................................................................

6、..................172.2染铝大鼠血铝、脑皮质和海马铝水平................................................................192.3染铝大鼠脑皮质和海马内Aβ的水平.................................................................212.4染铝大鼠脑皮质和海马内BACEmRNA和BACE蛋白表达的变化...............242.5染铝大鼠脑皮质和海马内miRNA29的表达..................

7、...................................263讨论...........................................................................................................................304结论....................................................................................................................

8、.......34第二部