组蛋白的甲基化 组蛋白甲基化

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1、组蛋白的甲基化组蛋白甲基化SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifardStowersInstituteforMedicalResearch,KansasCity,MO64110,USAYeast(S.cerevisiae.cerevisiae)Biochemical/biologicalpropertiesSETDB1CAF1HeterochromatinHP1formation/s

2、ilencingMethylaseSubstrate14DrosophilaMammalsKMT1H3K9NotdetectedSu(var)3-9Su(var)3G9aSUV39H1/2SETDB1ATF7IPKMT1A/BKMT1A/BKMT1CKMT1EG9AGLPKMT1C/DCps40KMT2H3K4Cps60Cps25Set1Cps50Cps35Cps30Dpy30Ash2TrxDpy30Rbbp5Set1Mnn1WdsRbbp5Wdr82Wds14Ash2Cxxc1ASH2DPY30ML

3、L1/2RBBP5MEN1WDR5CXXC1ASH2SET1A/BDPY30RBBP5Activetranscription;homeoticgeneexpression;nuclearhormonereceptorsignalingKMT2A/BHcfLptAsh2Dpy30UtxTrrRbbp5Pa1PtipWdsKMT2F/GKMT2A/BWDR82WDR5HCF1ASH2DPY30UTXPA1MLL3/4RBBP5PTIPWDR5NCOA6KMT2F/GKMT2C/D14ySet1/COMPA

4、SSSet2KMT3H3K36CTDRNAPolIICTDRNAPolIIDrosophilaCOMPASSFamilySet2Mes-4KMT2C/DMammalianCOMPASSFamilySET2CTDRNAPolIIWHSC1ActivetranscriptionKMT3AKMT3AKMT3AAF10AF9DOT1TRRAPAF17ENL14KMT3BKMT4H3K79Dot1GrappaActivetranscription;cell-cycleregulation;Wntsignalin

5、gKMT4KMT4KMT4DotComKMT5H4K20NotdetectedPR-Set7Su(var)4-20PR-Set7SUV4-20H1/H2Transcriptionalrepression;DNAdamageresponseKMT5AKMT5B/CKMT5AKMT5B/CSu(z)12Nurf55KMT6H3K27NotdetectedJingPclJarid2E(z)14Esc/EsclRBBP4/RBBP7AEBP2SUZ12EZH1/EZH2EEDJARID2Polycombsil

6、encing;Xchromosomeinactivation;cellfatedeterminationPHF1MTF2PHF19KMT6KMT6S-adenosyl-L-methionineS-adenosyl-L-methionineS-adenosyl-L-methionineCH3CH3CH3CH3CH3CH3KMTKMTKMTMonomethylation(me)Dimethylation(me2)Trimethylation(me3)498Cell149,April13,2012©2012

7、ElsevierInc.DOI10.1016/j.cell.2012.03.025Seeonlineversionforlegendandreferences.SnapShot:HistoneLysineMethylaseComplexesManMohan,Hans-MartinHerz,andAliShilatifard14StowersInstituteforMedicalResearch,KansasCity,MO64110,USALysinemethyltransferases(KMTs)ca

8、talyzethetransferofone,two,orthreemethylgroupsfromS-adenosyl-L-methionine(SAM)totheε-aminogroupofalysineresidueonahistonetogeneratemono-,di-,andtrimethylatedhistones.KMTsexisteithersinglyorwithincomplexes,inwhichthemembersofeachc