督灸治疗强直性脊柱炎抑制HLAB27基因表达的临床研究

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1、山东中医药大学硕士学位论文督灸治疗强直性脊柱炎抑制HLA-B27基因表达的临床研究姓名：申玮红申请学位级别：硕士专业：针灸推拿学指导教师：崇桂琴2003.4.20提要本文主要观察督灸治疗强直性脊柱炎(ankylosingspondylifts，简称AS)对HLA．B27基因表达的影响。／将临床上诊断为AS而且HLA．B27阳性的60例患者随k机分为两组，督灸组和对照组。督灸组30例，以督灸治疗为主，配合饮食调节和功能锻炼；对照组30例，以饮食调节为主，配合功能锻炼。两组均以3个月为一疗程。、丘^一

2、治疗前后均检测HLA．B27、NK细胞、ESR、CRP、Ez等指标。)研究发现，督灸组在／缓解临床症状、改善体征及实验室指标方面，与对照组比较均有显著性差异(JP

3、表达，遏制HLA．B27递呈携带细菌多肽复合物或自身肽给CD8+T细胞而发生的免疫反应，对AS具有治病求本的确切疗效。关键词督灸：强直性脊柱炎；临床研究；HLA_B27抗原；NK细胞、ClinicalStudyonDu-moxibustioninTreatingAnkylosingSpondylilisbyInhibitingGeneExpressionofHLA-B27Speciality：acupunctureandmoxibustionAuthor：ShenWeihongTutor：Chon

4、gGuiqinAbstractobjeefiveToobservetheeffectongeneexpressionofHLA-B27intreatingAnkylosingSpondylitiswithDu·moxibustion．Metheds60patientswithAnkylosingSpondylifisandpositiveHLA-B27weredividedintotwogroupsbyrandom，amongthesepatients．testgroup(30cases)were

5、treatedby血一moxibusfion,dietotherapyandfunctionalexercise，controlgroup(30eases)weretreatedonlybydietotherapyandfunctionalexercise．AcourseoftreatmentWaSthreemonthsforbothgroups．ThelevelsofHLA-B27，naturalkiller(NK)cell，estradiol(E2)，erythrocytesedimentat

6、ionrate(ESR)andcreactiveprotein(CRP)weredetectedbeforeandafteracourseoftreatmentforeachgroup．ResultsDu-moxibustioncarlimproveclinicalsymptoms，mainphysicalsignsandlaborarymarkersofpatientsobviously,especiallyininhibitingthegeneexpressionofHLA-B27,thedi

7、fferencewassignificantcomparedtothecontrolgroup；Meanwhile，thelevelofNKcellwasascended,thelevelsofESRandCRPweredescendedcomparedtothatofthepretherapy,andthedifferenceWassignificantcomparedtothecontrolgroup．Itshowedtheefficiencyoftestgroupissignificantl

8、ysuperiortothatofcontrolgroupina由ustingtheimmunologicalfunctionandendocrinesystem．ConclusionDu—moxibustionintreatingAnkylosingSpondylitishascertaineffectbyinhibitingthegeneexpressionofHLA_B27inadjustingimmunologicalfunctionandendocrinesystem，a