《旋毛虫丝虫》PPT课件

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1、ReviewofintestinalhelminthsAscarislumbricoides(roundworm)似蚓蛔线虫（蛔虫）Trichuristrichiura(whipworm)毛首鞭形线虫（鞭虫）Enterobiusvermicularis(pinworm)蠕形住肠线虫（蛲虫）AncylostomaduodenaleNecatoramericanus(hookworms)钩虫Trichinellaspiralis旋毛形线虫Tissue-blooddwellingnematodes--Filaria丝虫Wu

2、chereriabancrofti班氏吴策线虫Onchocercavolvulus旋盘尾丝虫ThehistoryofTrichinellaspiralisInyear1835，YoungJimPaget,afirstyearmedicalstudentatLondonHospitalMedicalSchool,rushedintotheautopsyroom.The51yr-oldItalianbricklayerwhohaddiedoftuberculosis,andthattheywerenowdissectin

3、g,alsohad"sandydiaphragm,"aconditionthatdulledeventhesharpestofscalpels.Well,anyway,whentheyhadallclearedtheroom,Jimquietlystolebackinandremovedasmallbitofmuscletissuefromthediaphragm.Hewasmorethancuriousastothenatureof"sandydiaphragm".Hefirstexamineditwithhist

4、rustyhandlenshecarriedforjustsuchasituation.Hethoughthesawsmallwormscoiledupinsideeachnodule.Uponevenhighermagnification,thepresenceofcoiledwormswasrevealed.(Fromwww.trichinella.org)TrichinellaspiralisJimPagetWormsinthe“sandydiaphragm”TrichinellaspiralisTrichin

5、awormswereobservedinporkin1846byJosephLeidy.Hesavedhundredsoflivesbyrecommendingcookingporkatahighenoughtemperaturetokilltheorganism.Lifecycleworkoutin1850’sByRudolphVirchow.TrichinellacontrolRudolfVirchow(Germany)suggestedmandatorydiagnosisofallmeatattheslaugh

6、terhousesin1877ThishasgreatlyreducedtrichinellosisashumanhealthProblem.WorldwideDistributionParasiticzoonosisFoodborneparasitosisTrichinellaspiralis-cause旋毛虫病trichinosis,trichiniasis,ortrichinelliasisDistributionofTrichinellaspiralisTrichinosisismostcommoninte

7、mperateandarcticclimates-highprevalenceinpork-eatingareasoftheworld.arctictemperateAdultsofTrichinellaspiralisAdults:small,1.5~4mmLarva:femalesgivebirthtolarva(Eggs:hatchinuterus子宫)stichosomeHatchedLarva杆状体成虫形态在诊断上无意义！特点：直接产幼虫Encystedlarva幼虫囊包--infectivestage0.

8、25~0.5mm×0.21~0.42mmLemonshape1~2larvainthecystLifecycleAdultfemaleinmucosaofsmallintestineTrichinacystsinskeletalmuscle骨骼肌Pathogenisis3stages：1.Invasion–1weekfirstsymptomsa