埃索美拉唑治疗胃食管反流病的临床观察

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1、第28卷第3期右江民族医学院学报Vol.28No.32006年6月JournalofYoujiangMedicalCollegeforNationalitiesJun.2006==================================================================埃索美拉唑治疗胃食管反流病的临床观察尹毅霞，周喜汉（右江民族医学院附属医院消化内科，广西百色533000）摘要：目的探讨不同剂量埃索美拉唑对胃食管反流病（GERD）的治疗效果。方法选择63例门诊及住院经电子胃镜证实为GERD患者（洛杉矶分级为A级和B级）随机分为三组。A组20例予以埃

2、索美拉唑20mg，每日2次；B组21例予以埃索美拉唑40mg，每日2次；C组22例予以埃索美拉唑20mg，每日2次，睡前40mg，分别观察患者治疗前及治疗后8周临床症状改善情况；治疗8周后行电子胃镜检查观察愈合率。结果三组临床症状均有明显改善，症状记分较治疗前显著下降（P均<0.01）。C组在症状消失率、总有效率以及内镜下食管炎愈合率和总有效率方面均高于A、B组，但差异无显著性。结论埃索美拉唑是治疗轻、中度GERD患者有效的药物，尤其加用夜间酸突破治疗，效果更佳。关键词：胃食管反流／治疗；埃索美拉唑；剂量效应关系，药物中图分类号：R571文献标识码：A文章编号：1001-5817（20

3、06）03-0360-03EsoLeprazoleingastroesophagealrefluxdiseaseYINYi-xia，ZHOUXi-han（DepartmentofGastroenterology，AffiliatedHospitalofYoujiangMedicalCollegeforNationalities，Baise，Guangxi533000，P.R.China）Abstract：ObjectiveTocompareclinicalefficacyofdifferentdosageofEsomeprazoleintreatmentofgastroe-sophag

4、ealrefluxdisease（GERD）.MethodsSixty-threepatientswithGERDprovenbygastroscopewereen-rolledinthisstudy.Theywererandomlyallocatedtothreegroups，groupA，BandC.TwentycasesingroupAre-ceivedtherapywithEsomeprazole20mg，twiceaday；twenty-onecasesingroupBweregivenEsomeprazole40mg，twiceaday；twenty-twocasesing

5、roupCweregivenEsomeprazole20mg，twiceaday，40mgbeforenightsleep-ing.Beforetreatmentand8weeksaftertreatment，theclinicalsymptomsandsignswereassessed，8weeksafterthetreatment，agastroscopewasusedtoexaminethehealingstate.ResultsSymptomreliefwasobtainedinallthethreegroups，bycomparisontotreatmentbefore，th

6、esymptomscoreswerelower（P<0.01）.IncomparisontogroupsAandB，highersymptomfreerate，totaleffectiverate，andendoscopicesophogitishealingrateandtotalef-fectiveratewerefound，buttherewerenostatisticallysignificantdifferences.ConclusionEsomeprazoleisanef-fectivedrugintreatmentofmild，moderateGERD，abetterre

7、sultwasobtainedplusnocturnalacidbreakthroughtreatment.Keywords：gastroesophagealreflux／therapy；esomeprazole；dose-responserelationship胃食管反流（GERD）是临床上常见的消化道疾病，其引起影响食道动力的药物。三组病人在年龄、性别和疾情严重程度的相关症状对pH值有高度依赖性，近50%的患者内镜下有糜差异无显著性（P>0