刘玉兰 益生元2011,12

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1、2011-12-3GIbarrier保护肠道健康－益生元及益生菌的作用北京大学人民医院刘玉兰1GutHealthGuthealthOnemightdefineguthealth:InAsianmedicine:guthealthisacentralthemetheabdomenasthelocationofthesoulAsastateofphysicalandmentalwell-beingIntheabsenceof：IntheWesternworld:1,GIcomplaintsthatrequiretheconsultationofadoctorguthealthismo

2、rethanjustapositivegutfeeling,2,Indicationsoforrisksforboweldiseaseasadesirableaimandanimportantphysiologicalcondition3,Confirmedboweldisease.requiredforoverallgoodhealthDrugDiscovToday2003MutatRes2007GenesNutr2007CurrDrugMetab2009Itisstillveryunclearwhatguthealthis,howitcanbedefinedandhowitcan

3、bemeasured.BischoffSC.BMCMed.2011Mar14;9:24.GutHealth肠粘膜屏障Twofunctionalentitiesarekeytoachievingand化学屏障----黏液maintainingguthealth.机械屏障----粘膜上皮.TheGImicrobiomeandtheGIbarrier（TJ和AJ:occludin和ZO-1）GIbarrierreferstoafunctionalentityconsistingof:生物屏障----正常的肠道菌群EpithelialdefenceMetabolicfunctionsThem

4、ucosalimmunesystem免疫屏障----sIgA和免疫细胞Theentericnervoussystem(ENS)12011-12-3人类肠道微生态asurfaceofapproximately300m2拟杆菌门厚壁菌门BacteroidetesFirmicutesGALT:largestlymphoidorgancontainingabout70%ofallimmuneNewConcept:cells(106lymphocytes/gramoftissue).MicrobiotaorganGut-associatedlymphoidtissueisthelarges

5、tlymphoidorganinthehumanBacteriaorganbody,containingabout70%ofallimmunecells(106lymphocytespergramoftissue).GALT,（gut-associatedlymphoidtissue）Valdés-RamosR,Martínez-CarrilloBE,Aranda-GonzálezII,etal.ProcNutrSoc.2010;69(4):644-50.MultiplefunctionsofgutmicrobiotaMainbeneficialfunctionsofthehum

6、angutmicrobiota14TheGImicrobiomeconsistsofabout10bacteriathataremainlylocatedinthelargeintestine.人体结肠细菌细胞细胞数量高达100万亿,是人体细胞数量的10倍。31245Circlesrepresentthethreeprincipalclassesoffunctionsperformedbythebacteriathatinhabitthegut.ArrowsrepresentcausalrelationshipsSatyaPrakash，LaetitiaRodes，MichaelCo

7、ussa-Charley，etal.Biologics:TargetsandTherapy2011:571–86LackofexerciseMucosaimmunehomeostasisandinflammationExtremeexerciseMaintenanceofnormalbodyweightcommensalGALT,（gut-ChronicassociatedmucosalcellsUnbalancedModeratealcoholconsu