当归多糖对大鼠急性肝损伤保护作用与机制分析

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1、目录摘要··········································································································1ABSTRACT··································································································4前言····································································

2、······································7第一部分当归多糖的提取、纯化与鉴定·························································91.当归粗多糖的提取···················································································92.当归多糖的纯化·······································································

3、··············103.当归多糖的鉴定·····················································································124.讨论与小结····························································································17第二部分当归多糖肝靶向的研究·····························································

4、·····181.当归多糖标荧光记物的制备·····································································192.当归多糖在大鼠肝实质细胞和非实质细胞中的分布·····································233.当归多糖在HEPG2细胞和HELA细胞中的摄入研究·····································324.讨论与小结····························································

5、································34第三部分当归多糖对急性肝损伤保护作用体内研究········································351.对乙酰氨基酚致大鼠急性肝损伤模型的建立···············································352.当归多糖对大鼠急性肝损伤保护作用药效学研究········································393.当归多糖对大鼠急性肝损伤保护作用分子机制研究·······························

6、······474.讨论与小结····························································································54第四部分当归多糖对急性肝损伤保护作用体外研究········································561.对乙酰氨基酚诱导肝细胞凋亡/坏死···························································562.当归多糖抑制肝细胞凋亡/坏死机制研究················

7、····································603.讨论与小结····························································································67总结与讨论··································································································68本论文创新点······················