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1、icrofluidicsandNanofluidics© Springer-Verlag 200910.1007/s10404-009-0421-xReviewMicro-injectionmouldingofpolymermicrofluidicdevicesUsama M. Attia1 , Silvia Marson1 and Jeffrey R. Alcock2 (1)CranfieldUniversity,Building56,WharleyEnd,Cranfield,Bedfordshire,MK430AL,UK(2)Cran
2、fieldUniversity,Building61,WharleyEnd,Cranfield,Bedfordshire,MK430AL,UK Usama M. Attia (Correspondingauthor)Email: u.attia@cranfield.ac.uk Silvia MarsonEmail: s.marson@cranfield.ac.uk Jeffrey R. AlcockEmail: j.r.alcock@cranfield.ac.ukReceived: 20 November 2008Accepted: 6 Feb
3、ruary 2009Publishedonline: 28 February 2009AbstractMicrofluidicdeviceshaveseveralapplicationsindifferentfields,suchaschemistry,medicineandbiotechnology.Manyresearchactivitiesarecurrentlyinvestigatingthemanufacturingofintegratedmicrofluidicdevicesonamass-productionscalewithrel
4、ativelylowcosts.Thisisespeciallyimportantforapplicationswheredisposabledevicesareusedformedicalanalysis.Micromouldingofthermoplasticpolymersisadevelopingprocesswithgreatpotentialforproducinglow-costmicrofluidicdevices.Amongdifferentmicromouldingtechniques,micro-injectionmould
5、ingisoneofthemostpromisingprocessessuitableformanufacturingpolymericdisposablemicrofluidicdevices.Thisreviewpaperaimsatpresentingthemainsignificantdevelopmentsthathavebeenachievedindifferentaspectsofmicro-injectionmouldingofmicrofluidicdevices.Aspectscoveredincludedevicedesig
6、n,machinecapabilities,mouldmanufacturing,materialselectionandprocessparameters.Problems,challengesandpotentialareasforresearcharehighlighted.Keywords Micro-injectionmoulding Microfluidics Polymers Polymerprocessing1 IntroductionMicrofluidicsisarapidlygrowingdomainwithmanyappl
7、icationsandastrongpotentialfordevelopment.ThevolumeofmicrofluidicproductswasestimatedtobeapproximatelyUS$600 millionin2006,andthemarketwasforecasttogrowtoUS$1.9 billionby2012(Becker 2008).Microfluidicdevicesarealreadyusedinanumberofdomains,includingchemistry,biotechnologyandm
8、edicine.Prototypelab-on-a-chip(LOC)systemsaredevelopingrapidlyinseve
