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1、PERSPECTIVESareaction–diffusionmechanism.I attribute10-YEARANNIVERSARYSERIES—VIEWPOINTthisconcepttoEricKarsenti,whomootedtheideainthemid1980sforsignalsdif-Adecadeofmolecularcellbiology:fusingawayfromDNAineggs.However,itwasn’tprovenuntilthedevelopmentofachievementsan
2、dchallengesfluorescenceresonanceenergytransfer(FRET)-basedactivitybiosensorsinthepastdecade2,3.Ingeneral,fluorescencesensorsAsifaAkhtar,ElaineFuchs,TimMitchison,ReubenJ. Shaw,DanielStJohnston,ofbiochemicalactivityareaveryimportantAndreasStrasser,SusanTaylor,ClaireWa
3、lczakandMarinoZerialdevelopment.Abstract
4、NatureReviewsMolecularCellBiologycelebratedits10‑yearanniversaryReuben J.Shaw.Oneareaclosetoourownduringthispastyearwithaseriesofspeciallycommissionedarticles.workistheunexpectedre-emergenceofTo complementthis,herewehaveasked
5、researchersfromacrossthefieldfortheirmetabolismanditsrelationshiptogrowthinsightsintohowmolecularcellbiologyresearchhasevolvedduringthispastcontrolandcancer.Advancesinautophagycontinuetoamazemeintermsofhowlittledecade,thekeyconceptsthathaveemergedandthemostpromising
6、interfacesbasicinformationweactuallyhaveonhowathathavedeveloped.Theircommentshighlightthebroadimpactthatparticularcellworks.Autophagyregulatorsarehighlyadvanceshavehad,someofthebasicunderstandingthatwestillrequire,andtheconservedproteinsinacentralcellbiologi-collabo
7、rativeapproachesthatwillbeessentialfordrivingthefieldforward.calprocessthatisderegulatedincommonhumandiseases,yetmuchofthebiochemi-calframeworkforthisprocesshasbeenWhatdoyoufeelhavebeentheTakahashiwereparadigm-shifting.Theirdecodedonlyrecently.Othernewlydecodedmosts
8、ignificant,andperhapsmostworkreportedthecreationofinducedpluri-centralregulatorsandprocesses,rangingsurprising,newconceptstoemergeinpotentstem(iPS)cellsfrommouseskinfromciliatosirtuins,microRNAs(miRNAs)molecularcellbiologyduringthepastdecade?fibroblastswhenculturedi
9、nembryonicstemandpathwayssuchasthoseinvolvingHasthisprogressbeenenabledbyaparticularcell(ESC)conditions1.ItwasremarkableHippoandmammaliant
