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1、OPENIn-linephase-contrastandgrating-basedphase-contrastsynchrotronimagingSUBJECTAREAS:CANCERIMAGINGstudyofbrainmicrometastasisofbreastIMAGINGANDSENSINGcancerReceived14November2014ShengHuang1*,BinquanKou2*,YayunChi1*,YanXi3,4,YixinCao2,WenliCui5,6,XinHu1,ZhiminShao1,AcceptedHanGuo7,YananFu7,T
2、iqiaoXiao7,JianqiSun3,JunZhao3,4,YujieWang2&JiongWu127February2015Published1DepartmentofBreastSurgery,BreastCancerInstitute,ShanghaiCancerCenter,DepartmentofOncology,ShanghaiMedical30March2015College,FudanUniversity,Shanghai,People’sRepublicofChina,2DepartmentofPhysicsandAstronomy,ShanghaiJi
3、aoTong3University,Shanghai,People’sRepublicofChina,SchoolofBiomedicalEngineering,ShanghaiJiaoTongUniversity,Shanghai,4People’sRepublicofChina,Med-XResearchInstitute,ShanghaiJiaoTongUniversity,Shanghai,People’sRepublicofChina,56DepartmentofPathology,FudanUniversity,ShanghaiCancerCenter,Shangh
4、ai,People’sRepublicofChina,DepartmentofCorrespondenceandPathology,FirstAffiliatedHospitalXinjiangMedicalUniversity,Urumqi,XinjiangUygurAutonomousRegion,People’sRepublicofrequestsformaterials7China,ShanghaiInstituteofAppliedPhysics,ChineseAcademyofSciences,Shanghai,People’sRepublicofChina.sho
5、uldbeaddressedtoJ.W.(wujiong1122@vip.sina.com)orCurrentbio-medicalimagingresearchesaimtodetectbrainmicrometastasisinearlystageforitsincreasingincidenceandhighmortalityrates.Synchrotronphase-contrastimagingtechniques,suchasin-lineY.J.W.(yujiewang@phase-contrast(IPC)andgrating-basedphase-contr
6、ast(GPC)imaging,couldprovideahighspatialandsjtu.edu.cn)densityimagingstudyofbiologicalspecimens’3Dstructures.Inthisstudy,wedemonstratedthedetectionefficienciesofthesetwoimagingtoolsonbreastcancermicrometastasisinanexvivomousebrain.WefoundthatbothIPCandGPCcandifferentiateabnormalbrainstructur
7、esinducedbymicrometastasisfromthe*Theseauthorssurroundingnormaltissues.WealsofoundthatGPCwasmoresensitiveindetectingthesmallmetastasisascontributedequallytocomparedtoIPC.thiswork.renewedfocusontheproblemofmetastasisisnowobvioussinceitisresponsiblef
