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1、TheSignificanceandTherapeuticPotentialofGATA3ExpressionandMutationinBreastCancer:ASystematicReviewFengDu,1∗PengYuan,1∗TengWang,2JiudaZhao,1ZitongZhao,3YangLuo,1andBingheXu11DepartmentofMedicalOncology,CancerHospital,ChineseAcademyofMedicalSciences,PekingUnionMe
2、dicalCollege,Beijing100021,China2TumorMarkerResearchCenter,CancerInstituteandHospital,ChineseAcademyofMedicalSciences,PekingUnionMedicalCollege,Beijing100191,China3StateKeyLaboratoryofMolecularOncology,CancerInstituteandHospital,ChineseAcademyofMedicalSciences
3、,PekingUnionMedicalCollege,Beijing100191,ChinaPublishedonlineinWileyOnlineLibrary(wileyonlinelibrary.com).DOI10.1002/med.21362Abstract:GATA3isacriticaltranscriptionfactorinthedevelopmentofvarioushumansystems.ThenotionthatGATA3expressionisrequiredforthediffere
4、ntiationandmaintenanceofnormalbreasttissuehasbeenwellestablished.Recently,GATA3isfoundtoactivelyparticipateinthemul-tistepprocessleadingbreastcancerpathogenesis,includingtumorigenesis,tumordifferentiation,ep-ithelialmesenchymaltransition,andmetastasisthroughre
5、gulationofvarioustargetgenes.Ontheotherhand,severalstudieshaveraisedquestionsandhighlightedtheroleofGATA3-loworGATA3-negativecellsduringthemalignantdevelopmentofbreastcancer.Inadditiontogeneexpression,GATA3mutationsprovideanotherdimensionofcomplexity.Asoneofth
6、emostfrequentlymutatedgenesinbreastcancer,GATA3mutationsmayhaveaneffectonDNA-bindingability,proteinproduction,andtransactivationactivity.RecognitionofthemultiplefunctionofGATA3inbreastcancerwillservetodeepenourunderstandingofthenatureofthisdiseaseanddevelopnov
7、eltherapeuticapproaches.C2015WileyPeriodicals,Inc.Med.Res.Rev.,0,No.0,116,2015Keywords:GATA3;breastneoplasm;mutation∗Boththeauthorscontributedequallytothiswork.Contractgrantsponsor:NationalNaturalScienceFoundation;Contractgrantnumber:81372830;Contractgrantspo
8、nsor:TheBeijingHopeRunSpecialFund;Contractgrantnumber:LC2013L09;Contractgrantsponsor:CapitalClinicalFeatureAppliedResearchFund;Contractgrantnumber:Z141107002514010.Correspondenceto
