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1、TheSignificanceandTherapeuticPotentialofGATA3ExpressionandMutationinBreastCancer:ASystematicReviewFengDu,1∗PengYuan,1∗TengWang,2JiudaZhao,1ZitongZhao,3YangLuo,1andBingheXu11DepartmentofMedicalOncology,CancerHospital,ChineseAcademyofMedicalSciences,PekingUnionMedicalCollege,Beijing100021,China2Tumo
2、rMarkerResearchCenter,CancerInstituteandHospital,ChineseAcademyofMedicalSciences,PekingUnionMedicalCollege,Beijing100191,China3StateKeyLaboratoryofMolecularOncology,CancerInstituteandHospital,ChineseAcademyofMedicalSciences,PekingUnionMedicalCollege,Beijing100191,ChinaPublishedonline27August2015i
3、nWileyOnlineLibrary(wileyonlinelibrary.com).DOI10.1002/med.21362Abstract:GATA3isacriticaltranscriptionfactorinthedevelopmentofvarioushumansystems.ThenotionthatGATA3expressionisrequiredforthedifferentiationandmaintenanceofnormalbreasttissuehasbeenwellestablished.Recently,GATA3isfoundtoactivelypar
4、ticipateinthemul-tistepprocessleadingbreastcancerpathogenesis,includingtumorigenesis,tumordifferentiation,ep-ithelialmesenchymaltransition,andmetastasisthroughregulationofvarioustargetgenes.Ontheotherhand,severalstudieshaveraisedquestionsandhighlightedtheroleofGATA3-loworGATA3-negativecellsduring
5、themalignantdevelopmentofbreastcancer.Inadditiontogeneexpression,GATA3mutationsprovideanotherdimensionofcomplexity.Asoneofthemostfrequentlymutatedgenesinbreastcancer,GATA3mutationsmayhaveaneffectonDNA-bindingability,proteinproduction,andtransactivationactivity.RecognitionofthemultiplefunctionofGA
6、TA3inbreastcancerwillservetodeepenourunderstandingofthenatureofthisdiseaseanddevelopnoveltherapeuticapproaches.C2015WileyPeriodicals,Inc.Med.Res.Rev.,35,No.6,13001315,2015Keywords:GATA3;breastneoplasm;mutation∗Boththeauthorscontributedequallytothiswork.Contractgrantsponsor:NationalNaturalScience
7、Foundation;Contractgrantnumber:81372830;Contractgrantsponsor:TheBeijingHopeRunSpecialFund;Contractgrantnumber:LC2013L09;Contractgrantsponsor:CapitalClinicalFeatureAppliedResearchFund;Contractgrantnumber:Z14110700251401
