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1、ClinicaChimicaActa431(2014)33–39ContentslistsavailableatScienceDirectClinicaChimicaActajournalhomepage:www.elsevier.com/locate/clinchimInvitedcriticalreviewInterleukin-17Ainlipidmetabolismandatherosclerosisa,1b,1cde,⁎,Chao-KeTanga,⁎⁎Xiao-HuaYu,NaJiang,Xi-LongZheng,FranciscoS.Cayabyab,Zhi-B
2、inTangaLifeScienceResearchCenter,KeyLaboratoryforAtherosclerologyofHunanProvince,UniversityofSouthChina,Hengyang,Hunan421001,ChinabDepartmentofElectrocardiogram,theSecondAffiliatedHospital,UniversityofSouthChina,Hengyang,Hunan421001,ChinacDepartmentofBiochemistryandMolecularBiology,TheLibin
3、CardiovascularInstituteofAlberta,TheUniversityofCalgary,HealthSciencesCenter,3330HospitalDrNW,Calgary,Alberta,T2N4N1,CanadadDepartmentofPhysiology,UniversityofSaskatchewan,Saskatoon,Saskatchewan,CanadaeDepartmentofOrthopedics,theFirstAffiliatedHospital,UniversityofSouthChina,Hengyang,Hunan4
4、21001,ChinaarticleinfoabstractArticlehistory:Interleukin-17(IL-17)A,themostimportantcytokineoftheIL-17familypredominantlysecretedbyThelper17Received18October2013(Th17)cells,playsacriticalroleinthedevelopmentofinflammatorydiseases.ItsreceptorisanobligateReceivedinrevisedform7January2014heter
5、odimercomposedofIL-17receptor(IL-17R)AandC,themainmembersoftheIL-17Rfamily.BindingAccepted9January2014ofIL-17AtotheIL-17RA/CcomplexcanactivateavarietyofdownstreamsignalingpathwayssuchasnuclearAvailableonline6February2014factorkappa-B(NF-κB),activatorprotein1(AP1)andCCAAT/enhancer-bindingpr
6、otein(C/EBP)toinducetheexpressionofproinflammatorycytokinesandchemokines.IL-17AalsopromotesmRNAstability.GrowingKeywords:IL-17AevidenceshowsthatIL-17Aisinvolvedinlipidmetabolismandthepathogenesisofatherosclerosis,achronicIL-17RAinflammatoryarterialdiseasedrivenbybothinnateandadaptiveimmunere
7、sponsestomodifiedlipoproteins.IL-17RCInthecurrentreview,wedescriberecentprogressonregulationandsignalingofIL-17A,andhighlightitsimpactsLipidmetabolismonlipidmetabolismandatherosclerosis.Atherosclerosis©2014ElsevierB.V.Allrightsreserved.Contents1.Introduction...
