RECENT PROGRESS IN THE SYNTHESIS OF ARTEMISININ AND ITS DERIVATIVES

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1、OrganicPreparationsandProceduresInternationalISSN:0030-4948(Print)1945-5453(Online)Journalhomepage:http://www.tandfonline.com/loi/uopp20RECENTPROGRESSINTHESYNTHESISOFARTEMISININANDITSDERIVATIVESByungJuKim&TomikazuSasakiTocitethisarticle:ByungJuKim&TomikazuSasaki(2006)RECENTPROGRE

2、SSINTHESYNTHESISOFARTEMISININANDITSDERIVATIVES,OrganicPreparationsandProceduresInternational,38:1,1-80Tolinktothisarticle:http://dx.doi.org/10.1080/00304940609355981Publishedonline:11Feb2009.SubmityourarticletothisjournalArticleviews:193ViewrelatedarticlesCitingarticles:3Viewciti

3、ngarticlesFullTerms&Conditionsofaccessandusecanbefoundathttp://www.tandfonline.com/action/journalInformation?journalCode=uopp20Downloadby:[HongKongPolytechnicUniversity]Date:01January2017,At:01:31ORGANICPREPARATIONSANDPROCEDURESINT,38(1).1-80(mRECENTPROGRESSINTHESYNTHESISOFARTEMI

4、SI"ANDITSDERIVATIVESByungJuKimandTomikazuSasaki*DepartmentofChemistryUniversityofWashington,Seattle.WA98195e-mail:sasaki@chem.washington.eduINTRODUCTION..........................................................................................................................31.His

5、toricalBackground.............................................................................................................32.ProposedModesofAction......................................................................................................43.CellularTargetsofArtemisi

6、ninsinMalariaParasites............................................................74.MetabolicStabilityandToxicityofArtemisininderivatives.................................................75.Structure-ActivityRelationships(SAR)......................................................

7、............................8I.SYNTHETICAPPROACHESTOARTEMISININDERIVATIVES................................91.GeneralOverview....................................................................................................................92.Dihydroartemisinin@HA)Derivatives....

8、........................................