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1、PulmonaryPerspectiveVitaminDBeyondBonesinChronicObstructivePulmonaryDiseaseTimetoActWimJanssens1,AnLehouck1,ClaudiaCarremans1,RogerBouillon2,ChantalMathieu2,andMarcDecramer112RespiratoryDivision,UniversityHospitalGasthuisberg;andClinicandLaboratoryofExp
2、erimentalMedicineandEndocrinology,KatholiekeUniversiteitLeuven,Leuven,BelgiumThediscoverythatthevitaminDendocrinesystemregulatesaveryfulfilledtheirpromises.Inviewofthedisappointingresultsoflargenumberofgenesandtheirassociatedbiologicalprocessesthesespeci
3、ficandexpensivedrugs,moreattentionshouldbeimprovesourinsightintothefundamentalroleofvitaminDandsunrefocusedonthepotentialofolderdrugsinnewindications.exposureforhumanhealth.AccumulatingepidemiologicaldataareStatins,angiotensin-convertingenzyme(ACE)–inhib
4、itors,andlinkingalowvitaminDnutritionalstatustohighlyprevalentdiseasesheparinesallhaveabroaderfieldofactionthaninitiallypre-suchascancer,autoimmunediseases,andchronicinfections.Ap-sumedandmaybecomeofinterestinthefuturetherapyofproximatelyhalfoftheworldse
5、lderly,andtoalesserextenttheCOPD(3,4).Inthisperspectivewewilldiscussthepotentialofadultpopulation,haveinsufficienttodeficient25-hydroxyvitaminDanother,evenoldermolecule,vitaminD.(25-OHD)serumlevels,andseveralinterventionstudiesarebeingAfterthedualoriginof
6、vitaminD(bysynthesisintheskinorundertakentostudytheimpactofadequatevitaminDsupplemen-bydietaryintake)wasunderstood,oralvitaminDsupplemen-tationinchronicdiseases.Inthisperspectiveweclaimthatchronictationalmostfullyeradicatedendemicrickets.Manyhealthobstr
7、uctivepulmonarydisease(COPD)isacandidatediseaseforcareprofessionalsthoughtthemajorhealthproblemsresultingwhichvitaminDsupplementationmightbebeneficial.Epidemio-fromvitaminDdeficiencyhadthusbeenresolved.However,logicalstudiesrevealedadose-dependentassociat
8、ionbetweenserum25-OHDlevelsandpulmonaryfunctionsothatadequateitturnedoutthatricketswasonlythetopoftheicebergandvitaminDsupplementationmayextendbeyonditsprotectionthatlessseverevitaminDdeficiencyisstillverycommonandagainstosteoporo
