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1、YBBRC30192No.ofPages7,Model5G15April2013BiochemicalandBiophysicalResearchCommunicationsxxx(2013)xxx–xxx1ContentslistsavailableatSciVerseScienceDirectBiochemicalandBiophysicalResearchCommunicationsjournalhomepage:www.elsevier.com/locate/ybbrc2BMPsignalattenuatesFGFpathwayinanteroposterior
2、neuralpatterninga,1b,⇑a,⇑3Q1Gun-SikCho,Sun-CheolChoi,Jin-KwanHan4aDivisionofMolecularandLifeSciences,PohangUniversityofScienceandTechnology,San31,Hyoja-dong,Nam-gu,Pohang,Kyungbuk790-784,RepublicofKorea5bDepartmentofBiomedicalSciences,UniversityofUlsanCollegeofMedicine,Pungnap-Dong,Songp
3、a-Gu,Seoul138-736,RepublicofKorea67articleinfoabstract20910Articlehistory:Invertebrateearlydevelopment,theneuraltissueisspecifiedalongtheantero-posterior(A-P)axisbythe2111Received8March2013activityofgradedpatterningsignalssuchasWnt,NodalandFGF.Attenuationofthesesignalshasbeen2212Available
4、onlinexxxxshowntoplaycriticalrolesinthedeterminationofanteriorneuralregion,butitremainspoorlyunder-23stoodhowFGFactioniscounteractedintheneuralplate.Here,weshowthatBMPsignalactsasanantag-2413Keywords:onistofFGFsignalingforAPneuralpatterninginXenopusembryo.Duringtheneurulastages,BMPsignal
5、2514BMPwasup-regulatedintheanteriorneuralplate,displayingagradedpatternalongtheAPaxis.Inhibitionof2615FGFthelateBMPsignalingaftermid-gastrulationabrogatedtheexpressionofanteriorneuralmarkers.We2716Flrt3foundthatBMPsignalinginterferedwithFGFs-inducedERKphosphorylationandneuralcaudalizatio
6、n.2817Neuralpatterning18XenopusThisinhibitoryactionofBMPsignalinvolvedrepressionoftheexpressionofFlrt3,apositiveregulator2919ofFGFsignaling.Furthermore,thegain-andloss-of-functionofFlrt3inhibitedandexpandedtheexpres-30sionofforebrainmarkergenes,respectively.Together,theseresultsdemonstra
7、tethatBMPsignalcan31down-regulateFGFpathwayviainhibitionofFlrt3expressionforanteriorneuralformation,revealing32stage-specificrolesofBMPsignalinganditsnovelcrosstalkwithFGFpathwayinneuraldevelopment.33Ó2013PublishedbyElsevierInc.343536371.Introductionpatterningbysecretingin
