血塞通络泰药理[1]

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1、IntroductionofPanaxNotoginsengSaponins（PNS）AnditsPreparations——PanaxNotoginsengInjection&PanaxNotoginsengSaponinsforInjectionZhiqiangSHENKUNMINGPHARMACEUTICALCORP.2003-09-17IthasbeenusedforhaemostasisandinvigorationforalongtimeintheChinesefolkandethn

2、icmedicine.PanaxNotoginseng(Sanqi)PanaxNotoginsengwasrecordedin“CompendiumofMateriaMedica”400yearsago.AsoneofraretraditionalChinesemedicines,itismainlyproducedinYunnanProvince(occupiedmorethan90%oftheoutput).PharmacologicalexperimentsshowthatPanaxnot

3、oginsenghastheeffectsofinvigoratingthecirculationofbloodandimprovingmicrocirculation,haemostasis,anti-inflammationandanalgesia.Asoneofthenaturalmedicines,PanaxnotoginsenosidesareextractedfromSanqi(Panaxnotoginseng)byseriesmodernpharmaceuticaltechnolo

4、gy,includingdunking,inspissating,absorbing,extracting,separating,crystalanddryness.PreparationsTablet;Softcapsule;Injection;Freeze-dryingpowderinjection,etc.ThesekindsofpreparationscontainingPanaxNotoginsenosideshavebeenappliedinclinicsfortreatingapo

5、plexyanditssequela(hemiplegia),deflectionofmouthandeyes，languageobstacle,chestpain(myocardialinfarction,coronaryheartdisease,andanginapectoris)，facialparalysisandophthalmocace.TheKeyPanaxNotoginsengSaponinsproductsofKPCincludePanaxNotoginsengSaponins

6、Injection(XuesaitongInjection)andfreeze-dryingpowderofPanaxNotoginsengSaponinsForInjection(Luotai®).PanaxNotoginsengSaponinsInjectionPanaxNotoginsengSaponinsInjection(XuesaitongInjection)DevelopedandmanufacturedfirstbyKPCintheearly80’sAcquiredthecert

7、ificateofnewdrugandauthorizationdocumentofproductionin1985ListedastheprotectedproductofStateTraditionalChineseMedicinesin1996RecordedintheStatePharmacopoeiaofChinain1998Specifications:100mg/2mL;200mg/2mL;250mg/5mL;250mg/10mLUsageandDosageIntravenousd

8、rip:Onceaday,200-400mg/Once,slowlydrippedafterdilutedin250-500mL(5%or10%)ofGlucoseInjectionIntravenousinjection:Onceaday,200mgeverytime,slowlyinjectedafterdilutedin40-60mL(25%or50%)ofGlucoseInjectionTheperiodoftreatmentis15dPanaxNotoginsengSaponinsfo